Mitotane

Also known as: Mitotanum

Drug #1997

Mitotane is an antineoplastic similar to the insecticide DDT; used for the treatment of inoperable adrenocortical carcinoma.

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Primary Characteristics

Mitotane is also known as Mitotanum.

Molecular Weight: 320.04 · Solubility in Water: 0.1mg/L · Non-proprietary name: Mitotane.

Pharmacokinetics

Absorption: Mitotane has an oral bioavailability is 40%.

Distribution: Mitotane has a plasma protein binding is 6%.

Elimination: plasma half-life is 18-159 days, renal excretion is 10-25%.

Indications

Mitotane is primarily indicated in conditions like Cushing's syndrome.

Contraindications

Mitotane is contraindicated in conditions like Hypersensitivity.

Dosage

Mitotane's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
4 g/day	4 g/day	Every 6h	PO	Initial dose
9 g/day	9 g/day	—	PO	Max tolerated dose
Paediatric Dosage (20kg)
3.5 – 1.5 g/m2	—	—		In divided doses,
Neonatal Dosage (3kg)
No data.

Drug Interactions

Moderate4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Mitotane produces potentially life-threatening effects which include Anemia, Thrombocytopenia , Leucopenia , Anemia. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Mitotane are Blurred vision, Polyneuropathy, Hyperpyrexia, Hypertension, Mycoses, Polyneuropathy, Retinopathy.

Mitotane is known to cause more or less tolerable side effects which are usually transient. These include Anemia, Anorexia , Ataxia, Confusion, Depression, Diarrhea, Diplopia, dizziness, Epigastric pain, Fatigue, Gynecomastia, Headache, Increased bleeding time, Lethargy, Nausea, Sedation , Sore mouth, Vertigo, Vomiting .

Warnings / Precautions

Avoid MITOTANE in severe liver disease Monitor serum concentration of MITOTANE in liver disease Manufacturer advises caution with MITOTANE in liver disease

Interference in Pathology

Mitotane may interfere in the diagnosis of Decreased level of 17-hydroxy-corticosteroids, Decreased protein-bound iodine levels.

Available Brands

None recorded.

Storage Conditions

Mitotane should be stored .

Drug Classification

1.8.2 — Cytotoxic (anti-neoplastic) drugs