Methylamphetamine

Also known as: Methamphetamine, Metamphetamine

Drug #1999

Methamphetamine is a sympathomimetic amine with CNS stimulant activity. Peripheral actions include elevation of systolic and diastolic blood pressures and weak bronchodilator and respiratory stimulant action. Drugs of this class used in obesity are commonly known as "anorectics" or "anorexigenics". It has not been established, however, that the action of such drugs in treating obesity is primarily one of appetite suppression.

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Primary Characteristics

Methylamphetamine is also known as Methamphetamine, Metamphetamine.

It is of Synthetic origin.

It is classified in Adrenergic Agonist Agent pharmacological group.

Molecular Weight: 149.23 · Non-proprietary name: Methylamphetamine.

Molecular structure of Methylamphetamine

Pharmacokinetics

Elimination: it is metabolised via Hepatic, plasma half-life is 9-15 hrs, renal excretion is Urine.

Indications

Methylamphetamine is primarily indicated in conditions like Hyperactivity, Narcolepsy.

Methylamphetamine is also indicated for secondary conditions like Obesity.

Contraindications

Methylamphetamine is contraindicated in conditions like Diabetes mellitus, Epilepsy, Hypertension, Hyperthyroidism, Cardiovascular disease, Arteriosclerosis.

Dosage

Methylamphetamine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
5 mg	5 mg	—		In 2 divided doses for obesity Before each meal.
22.5 mg	22.5 mg	—	PO
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Major2 interactions

Minor1 interaction

Moderate5 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Methylamphetamine in overdosage may give rise to further complications which include Tachycardia , Allergic reactions , Restlessness , Irritability , Chest pain , Nervousness , Tremors , Tachycardia.

Methylamphetamine produces potentially life-threatening effects which include Heart failure, Liver stroke. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Methylamphetamine are Tachycardia , Palpitations , Tremor, Hypertension, Dysphoria , Euphoria , Hyperflexia , Urticaria.

Methylamphetamine is known to cause more or less tolerable side effects which are usually transient. These include Constipation , Diarrhea, dizziness, Dry mouth, Headache.

Warnings / Precautions

Methamphetamine tablets should be used with caution in patients with even mild hypertension. Methamphetamine should not be used to combat fatigue or to replace rest in normal persons. Prescribing and dispensing of methamphetamine should be limited to the smallest amount that is feasible at one time in order to minimize the possibility of overdosage. Tolerance to the anorectic effect usually develops within a few weeks. When this occurs, the recommended dose should not be exceeded in an attempt to increase the effect; rather, the drug should be discontinued

Available Brands

None recorded.

Storage Conditions

Methylamphetamine should be stored Tablets.

Drug Classification

1.21.4.3 — Sympathomimetics