Methylergonovine

Also known as: Methylergometrine maleate, Methylergonotivine maleate

Drug #1996

Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus.

← Previous drug Next drug →

Primary Characteristics

Methylergonovine is also known as Methylergometrine maleate, Methylergonotivine maleate.

It is of Semi Synthetic origin and belongs to Amine alkaloid.

Molecular Weight: 339.43 · Solubility in Water: 1 in 400 · Solubility in Alcohol: 1 in 140 · Non-proprietary name: Methylergonovine.

Pharmacokinetics

Absorption: Methylergonovine has an oral bioavailability is 50% (±50%), pre-systemic (first-pass) metabolism accounts for 35% (±5%).

Distribution: Methylergonovine has a volume of distribution is 0.33-0.6 l/kg-1. plasma protein binding is 35%.

Elimination: it is metabolised via Hepatic, plasma half-life is 0.5-2 hrs.

Indications

Methylergonovine is primarily indicated in conditions like Postpartum haemorrhage.

Contraindications

Methylergonovine is contraindicated in conditions like Hypertension, Toxaemia of pregnancy, Hypersensitivity, Pregnancy.

Dosage

Methylergonovine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.28 mg	0.28 mg	—	IV/IM	May be repeated as required, at intervals of 2-4 hours.
0.2 mg	0.2 mg	Every 6h	PO
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Major2 interactions

Moderate4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Methylergonovine in overdosage may give rise to further complications which include Hallucinations , Hallucinations , Severe allergic reaction, Blood in the urine.

Methylergonovine produces potentially life-threatening effects which include Coma, Seizures . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Methylergonovine are Diarrhea, Hematuria, Confusion , Hallucinations , Palpitations , Dizziness, Hypertension, Tinnitus , Tinnitus, Dyspnea, Myocardial infarction.

Methylergonovine is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Dizziness, Headache, Hypotension , Nausea and vomiting, Seizures, Vertigo.

Warnings / Precautions

This drug should not be administered I.V. routinely because of the possibility of inducing sudden hypertensive and cerebrovascular accidents. Caution should be exercised in the presence of sepsis, obliterative vascular disease, hepatic or renal involvement. Also use with caution during the second stage of labor. The necessity for manual removal of a retained placenta should occur only rarely with proper technique and adequate allowance of time for its spontaneous separation.

Available Brands

None recorded.

Storage Conditions

Methylergonovine should be stored Tablets. Ampules.

Drug Classification

1.22.1.1 — Oxytocics