Metipranolol

Also known as: Metipranolol Hydrochloride, Trimepranol

Drug #1993

Metipranolol is a beta1 and beta2 (non-selective) adrenergic receptor-blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. Metipranolol is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Metipranolol, when applied topically to the eye, has the action of reducing elevated, as well as normal, intraocular pressure, whether or not accompanied by glaucoma. Metipranolol reduces intraocular pressure with little or no effect on pupil size or accommodation in contrast to the miosis which cholinergic agents are known to produce.

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Primary Characteristics

Metipranolol is also known as Metipranolol Hydrochloride, Trimepranol.

Molecular Weight: 309.4 · Solubility in Water: Insoluble · Solubility in Alcohol: Soluble · Non-proprietary name: Metipranolol.

Pharmacokinetics

Elimination: it is metabolised via Liver.

Indications

Metipranolol is primarily indicated in conditions like Ocular hypertension, Open-angle glaucoma.

Contraindications

Metipranolol is contraindicated in conditions like Cardiogenic shock, Cardiac failure, Bradycardia, Obstructive pulmonary disease, Bronchial asthma, Hypersensitivity to any component of product.

Dosage

Metipranolol's dosage details are as follows:

Dose	Single Dose	Frequency	Route
Adult Dosage
0.2 5	0.2 5	Every 12h	Opthalmic
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

3 interactions

Major4 interactions

Moderate10 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Metipranolol in overdosage may give rise to further complications which include Conjunctivitis, Conjunctival Leucoplakia.

The signs and symptoms that are produced after acute overdosage of Metipranolol are Bradycardia, Uveitis, Hypertension, Cardiac failure, Atrial fibrillation, Myocardial infarction.

Metipranolol is known to cause more or less tolerable side effects which are usually transient. These include Abnormal vision, Allergic reactions, Arthiritis, Blurred vision, Bronchitis , Depression, Dyspnea, Edema, Headache, Nausea, Photophobia , Rashes , Rhinitis .

Warnings / Precautions

Metipranolol, or other beta-blockers, should not, in general, be administered to patients with chronic obstructive pulmonary disease (e.g., chronic bronchitis, emphysema) of mild or moderate severity. Because of potential effects of beta-adrenergic receptor blocking agents relative to blood pressure and pulse, these agents should be used with caution in patients with cerebrovascular insufficiency. If signs or symptoms suggesting reduced cerebral blood flow develop following initiation of therapy with metipranolol, alternative therapy should be considered. Patients should be instructed to avoid allowing the tip of the dispensing container to contact the eye or surrounding structures. Patients should be advised that Metipranolol contains benzalkonium chloride which may be absorbed by soft contact lenses. Contact lenses should be removed prior to administration of the solution. Lenses may be reinserted 15 minutes following OptiPranolol administration.

Available Brands

None recorded.

Storage Conditions

Metipranolol should be stored Tablets.

Drug Classification

1.12.2 — Antiarrhythmic drugs
2.12.3.1 — Beta blocking agents