Metrizamide
Metrizamide is an iodinated nonionic monomeric contrast medium that has been used in myelography, angiography, intravenous urography, and arthrography, and also for contrast enhancement during computed tomography.
Primary Characteristics
It is of Synthetic origin.
Molecular Weight: 789.1 · Non-proprietary name: Metrizamide.
Pharmacokinetics
None recorded.
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Indications
Metrizamide is primarily indicated in conditions like Angiography, Arthrography, Cisternography, Diagnostic procedures, Myelography.
Contraindications
Metrizamide is contraindicated in conditions like Comatose states.
Dosage
Metrizamide's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 10 mL | 10 mL | — | IT | Cervical myelography by lumbar injection: 10 mL of a solution containing the equivalent of 250 to 300 mg of iodine per mL. |
| 12 mL | 12 mL | — | IT | Thoracic myelography by lumbar injection: 12 mL of a solution containing the equivalent of 220 mg of iodine per mL. |
| 12.5 mL | 12.5 mL | — | IT | Myelography: 10 to 15 mL of a solution containing the equivalent of 170 to 190 mg of iodine per mL |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
The signs and symptoms that are produced after acute overdosage of Metrizamide are Heart failure. , Allergic skin reactions.
Metrizamide is known to cause more or less tolerable side effects which are usually transient. These include Backache , Chills, Diarrhea, Dizziness, Flushing, Loss of appetite, Unusual tiredness.
Warnings / Precautions
Interference in Pathology
Metrizamide may interfere in the diagnosis of Thyroid Function Test.
Available Brands
None recorded.
Drug Classification
- 1.14.2 — Radiocontrast media