Clotrimazole

Drug #192

Clotrimazole is imidazole deriative that is a broad spectrum fungicidal drug. Clotrimazole is most valuable for the treatment of superficial fungal infection caused by dermatophytes, yeasts, and yeast like fungi. Clotrimazole is a topically used azole. The requirement for intravenous administration and the toxicity of the older antifungal agents created a need for antifungal agents with a better therapeutic profile. The relatively non-toxic oral azole medications represent the first major advance in this direction. Since their introduction in the 1980s, these medications have played an increasingly important role in the systemic therapy of fungal disease.

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Primary Characteristics

Clotrimazole is also known as mycelax, canifug.

It is of Synthetic origin and belongs to Imidazole.

It is classified in Antifungals pharmacological group. It is also classified under Dermatological Products .

Molecular Weight: 344.8 · Solubility in Water: < 1 in 10000 · Solubility in Alcohol: > 1 in 10 · Non-proprietary name: Clotrimazole.

Pharmacokinetics

Distribution: Clotrimazole has a volume of distribution is 1 l/kg. plasma protein binding is 50%.

Elimination: it is metabolised via rapid & extensive, hepatic, renal excretion is 10% (24hr), 25% (6 days).

Indications

Clotrimazole is primarily indicated in conditions like Advanced breast or prostate cancer, Erythrasma, Leishmaniasis, Mucocutaneous candidiasis, Oropharangeal candidiasis, Orophyrangeal candidiasis, Tinea corporis, Tinea cruris, Tinea pedis, Tinea versicolor, Trichomonal vaginitis, Vaginitis, Yeast infection.

Clotrimazole is also indicated for secondary conditions like Dermatophytic infections.

Contraindications

Clotrimazole is contraindicated in conditions like Hypersensitivity.

Dosage

Clotrimazole's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1 % w/w	1 % w/w	Every 24h	Intra Vaginal	Apply at bedtime fpr 6-14 consecutive days.
100 mg	100 mg	Every 24h	Intra Vaginal	For 6-7 consecutive days or 500mg single dose at bedtime
200 – 0 mg	—	—	PO	Apply at bedtime fpr 6-14 consecutive days.
0.5 %w/w	0.5 %w/w	Every 24h	Topical	Apply to affected area.
Paediatric Dosage (20kg)
1 %	1 %	Every 8h	Topical
Neonatal Dosage (3kg)
1 %	1 %	Every 8h	Topical

Drug Interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Clotrimazole is known to cause more or less tolerable side effects which are usually transient. These include Abdominal cramps, Burning, Chemical cystitis, Contact dermatitis, Depression, Diarrhea, Disorientation, Elevated alkaline phosphatase, Elevated hepatic transaminases, Elevated serum llipids, GI irritation, Hallucination , Hypersensitivity rash, Nausea, Polyuria, Pruritus , Sedation , Skin irritation, urethral irritation, Vaginal irritation, Vision disturbances, Vomiting .

Warnings / Precautions

Clotrimazole should be used cautiously during pregnancy. It should be used with caution in patients with medical history or allergies. Self-administration of clotrimazole for longer than 7 days is contraindicated. If there is no improvement in the condition after 3 days, or if the condition persists after 7 days, patient should discontinue the clotrimazole therapy and consult a physician. Topical application of clotrimazole is contraindicated in the children under the age of 2, unless recommended by the physician.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Cream

1 %w/w 10 %w/w 2 %w/w

Lotion

Soln

Syrup

Tabs

Vag Cream

1 %w/w 10 %w/w 2 %w/w 50 %w/w

Vag Tabs

100 mg

Vag Tabs

500 mg

Multi-Ingredient Combinations

Cream

1 %w/w

Lotion

0.1 %w/v

Vag Cream

1 %w/w

Storage Conditions

Clotrimazole should be stored Oint, Cream, Soln.

Drug Classification

1.6.3 — Antifungal drugs
2.13.1 — Antifungals, topical
3.22.2 — Gynecological anti-infectives