Clopamide

Drug #190

Clopamide is a diuretic reduces the absorption of electrolytes from renal tubule. It increases the urination. Clopamide is used in hypertention to lower the high blood pressure and to treat edema associated with heart failure.

← Previous drug Next drug →

Primary Characteristics

It is of Synthetic origin and belongs to Piperidinyl Benzamide.

It belongs to NaCl cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Diuretic Thiazide pharmacological group.

Molecular Weight: 345.8 · Solubility in Water: 1 in 250 · Non-proprietary name: Clopamide.

Pharmacokinetics

Absorption: Clopamide has an oral bioavailability is 100%.

Distribution: Clopamide has a volume of distribution is 2.5 l/kg. plasma protein binding is <50%.

Elimination: it is metabolised via complex, plasma half-life is 10 hr, renal excretion is 30-40%.

Indications

Clopamide is primarily indicated in conditions like Congestive heart failure, Hepatic disease, Mild to moderate hypertension.

Contraindications

Clopamide is contraindicated in conditions like Gout, Maturity onset diabetes, Hypersensitivity.

Dosage

Clopamide's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.214 mg/kg	0.214 mg/kg	Every 12h	PO	As Required
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown1 interaction

3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Clopamide in overdosage may give rise to further complications which include Hyperglycemia , Precipitation of gout , Hyperglycemia, Hypokalemia .

Clopamide produces potentially life-threatening effects which include Decreased BP , Coronary insufficiency. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Clopamide are No cases have been reported.

Clopamide is known to cause more or less tolerable side effects which are usually transient. These include Gout, Hepatic failure, Renal failure.

Warnings / Precautions

The drug should be used with extreme caution in diabetic patients because clopamide can worsen diabetic control, raising blood sugar level and may precipitate gout. It should be used with caution in combination with other antihypertensive drugs such as thiazide and loop diuretics, as it increases the urinary excretion of potassium and can cause hypokalemia, potassium supplements are used to treat hypokalemia.

Interference in Pathology

Clopamide may interfere in the diagnosis of Changes in plasma & white cell copper & zinc concentration..

Available Brands

Click on a strength to view available brands.

Multi-Ingredient Combinations

Tabs

5 mg

Storage Conditions

Clopamide should be stored Tab.

Drug Classification

1.12.4 — Drugs used in heart failure
2.16.1 — Thiazide and related diuretics

Manufacturers

Manufacturers of Clopamide in Pakistan:

Novartis