Amphetamine

Drug #1897

Amphetamine was synthesized in 1887 by Lazar Edeleanu at the University of Berlin,initially it was used to diminish the appetite and to control weight .The drug is also used illegally as a recreational drug and as a performance enhancer.It is used by U.S military to combat fatigue and increase wakefulness.

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Primary Characteristics

It is of Synthetic origin.

It is classified in Syumpathomimetic pharmacological group.

Molecular Weight: 135.21 · pK_a: 10.1 · Solubility in Water: Slightly soluble · Non-proprietary name: Amphetamine.

Pharmacokinetics

Distribution: Amphetamine has a plasma protein binding is 15-40%.

Elimination: it is metabolised via Hepatic, plasma half-life is 10 hrs.

Indications

Amphetamine is primarily indicated in conditions like Attention deficit hyperactivity disorder, Narcolepsy.

Contraindications

Amphetamine is contraindicated in conditions like Hyperthyroidism, Arteriosclerosis, Alcohol abuse, Glaucoma.

Dosage

Amphetamine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.9 mg/kg daily	0.9 mg/kg daily	—	Oral	For Attention Deficit Hyperactivity Disorder: Conventional tablets: Rarely dose may be exceed to 40 mg daily. Tolerance is more likely with relatively high dosages. Long-term use has not been studied systematically. If used for long-term therapy, periodically reevaluate the usefulness of the drug.
32.5 mg daily	32.5 mg daily	—	Oral	For Nacrolepsy: Conventional tablets: Should be given in divided doses.Initially, 10 mg daily; daily dosage is increased in 10-mg increments at weekly intervals until the optimum response is attained.
60 mg daily	60 mg daily	—	Oral	For Attention Deficit Hyperactivity Disorder: Extended release capsules: Dosages up to 60 mg daily have been evaluated in clinical studies; however, no evidence that dosages >20 mg daily provide any additional benefit. Long-term use (>4 weeks) has not been studied systematically. If used for long-term therapy, periodically reevaluate the usefulness of the drug.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Major1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

The signs and symptoms that are produced after acute overdosage of Amphetamine are Seizures, Irregularities in heart rhythm, Confusion , Hallucinations , Tremor, Rapid breathing, Restlessness , Agressive behavior.

Amphetamine is known to cause more or less tolerable side effects which are usually transient. These include Anxiety, Constipation , Diarrhea, Headache, Impotence, Insomnia.

Warnings / Precautions

It is habit forming,you can become physically and psycologically dependent on this medication. Amphetamines may impair the ability of the patient to engage in potentially hazardous activities such as operating machinery or vehicles, the patient should therefore be cautioned accordingly.Prescribers or other health professionals should inform patients, their families, and their caregivers about the benefits and risks associated with treatment with amphetamine and should counsel them in its appropriate use

Available Brands

None recorded.

Storage Conditions

Amphetamine should be stored Tabs, Extended release capsules, Caps.

Drug Classification

1.21.4.3 — Sympathomimetics
2.24.5 — Psychostimulants, nootropics, and neurotonics