Methazolamide

Drug #1860

Methazolamide is an inhibitor of carbonic anhydrase.It is a sulfonamide derivative;however it does not have any clinically significant antimicrobial properties.

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Primary Characteristics

It belongs to Carbonic Anhydrase Inhibitor pharmacological group on the basis of mechanism of action.

Molecular Weight: 236.3 · pK_a: 7.30 · Solubility in Water: Slightly soluble · Solubility in Alcohol: Sligthly soluble · Non-proprietary name: Methazolamide.

Pharmacokinetics

Distribution: Methazolamide has a plasma protein binding is 55%.

Elimination: plasma half-life is Approx. 14 hours, renal excretion is 15-30 %.

Indications

Methazolamide is primarily indicated in conditions like Glucoma, Metabolic alkalosis, Urinary alkalinization.

Methazolamide is also indicated for secondary conditions like Epilepsy.

Contraindications

Methazolamide is contraindicated in conditions like Adrenal failure, Liver damage, Hyperchloremic acidosis.

Dosage

Methazolamide's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
75 mg	75 mg	Every 12h	oral	2 or 3 times daily by mouth.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Methazolamide in overdosage may give rise to further complications which include Hypokalemia , Hyponatremia , Hyponatremia.

The signs and symptoms that are produced after acute overdosage of Methazolamide are Dizziness.

Methazolamide is known to cause more or less tolerable side effects which are usually transient. These include Fatigue, Fever, Hearing disturbances, Malaise, Nausea, Thirst, Tingling of the fingers and toes, Vomiting .

Warnings / Precautions

Caution is to be taken when driving or operating dangerous machinery,and in patients on steroid therapy because of potential for developing hypokalemia.

Interference in Pathology

Methazolamide may interfere in the diagnosis of Serum electrophoresis , Complete blood cell count.

Available Brands

None recorded.

Storage Conditions

Methazolamide should be stored .

Drug Classification

1.16.5 — Carbonic anhydrase inhibitors