methoxyflurane
Methoxyflurane is a general inhalation anesthetic used for the induction and maintainence of general anesthesia.It induces muscle relaxation and reduces pain sensitivity by altering tissues excitibilty.It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels.
Primary Characteristics
It is of Synthetic origin and belongs to Fluronated hydrocarbon.
Molecular Weight: 165 · Solubility in Water: 1:500 · Solubility in Alcohol: Miscible · Non-proprietary name: methoxyflurane.
Pharmacokinetics
Elimination: it is metabolised via 50-70%.
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Indications
methoxyflurane is primarily indicated in conditions like Labor pains, Pain in short surgical procedure., Trauma.
Contraindications
methoxyflurane is contraindicated in conditions like Respiratory depression, Cardiovascular disease, Unconciousness, Head injury, Hypersensitivity.
Dosage
methoxyflurane's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 6 ml | 6 ml | — | ||
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
methoxyflurane in overdosage may give rise to further complications which include Nephrotoxicity , Renal failure , Increased serum creatinine , Laryngospasm, Oxaluria.
The signs and symptoms that are produced after acute overdosage of methoxyflurane are Bradycardia, Hypotension, Respiratory depression, Respiratory depression, Cardiac arrest, Respiratory depression, Malignant hyperthermia.
methoxyflurane is known to cause more or less tolerable side effects which are usually transient. These include Coughing, dizziness, Drowsiness, Fever, Nausea, Polyuria, Vomiting .
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.1.1.2 — Inhalational anesthetics