Clomiphene (Citrate)
Also known as: Clomifene (Citrate)
Clomiphene is a synthetic gonad stimulating principle structurally related to the proestrogen chlorotrianisene, consisting of a mixture of trans and cis isomers. Clomiphene (Citrate) is effective in treating infertility. It increases the secretion of gonadotropins and estrogens. It can also be used as a diagnostic agent. Administered orally.
Primary Characteristics
Clomiphene (Citrate) is also known as Clomifene (Citrate), chloramiphene, chloromifene, chlomaphene, zulcomiphene citrate.
It is of Synthetic origin and belongs to Triaryl Ethylene.
It belongs to Oestrogen antagonist pharmacological group on the basis of mechanism of action and also classified in Ovulation Stimulation pharmacological group. It is also classified under Sex Hormones .
Molecular Weight: 598.1 · Solubility in Water: slight · Solubility in Alcohol: 1 in 40 · Non-proprietary name: Clomiphene (Citrate).
Pharmacokinetics
Elimination: it is metabolised via via liver, plasma half-life is 5 days, renal excretion is mean urinaray excreation 8%.
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Indications
Clomiphene (Citrate) is primarily indicated in conditions like Anovulatory infertility, Polycystic ovary syndrome.
Clomiphene (Citrate) is also indicated for secondary conditions like Secondary amenorrhoea.
Contraindications
Clomiphene (Citrate) is contraindicated in conditions like Hyperprolactinaemia, Hepatic disease, Ovarian cysts, Abnormal uterine bleeding, Congenital disorders of bile disorders, Pituitary tumor.
Dosage
Clomiphene (Citrate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 50 mg | 50 mg | Every 24h | PO | Initially For 5 Days |
| 100 mg | 100 mg | Every 24h | PO | Maintenance for 5-Days |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Inidicated in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | — | Not Inidicated in this Age Group |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Clomiphene (Citrate) in overdosage may give rise to further complications which include Ovarian enlargement , Rupture of lutein cysts , Intraperitoneal hemorrhage , palvic pain.
Clomiphene (Citrate) produces potentially life-threatening effects which include Ovarian hyperstimulation, ovarian cancer. Careful monitoring is needed with proper medical management.
Clomiphene (Citrate) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal discomfort, Blurring of vision, Breast tenderness, Depression, Dizziness, Hot flushes, Loss of hair, Nausea, Rashes , sco to mota, Weight gain.
Warnings / Precautions
Interference in Pathology
Clomiphene (Citrate) may interfere in the diagnosis of Increased in Serum Aminotransferase.
Available Brands
Storage Conditions
Drug Classification
- 1.18.4 — Estrogens, their combinations and related preparations
- 2.18.6 — Ovulation stimulants
Manufacturers
Manufacturers of Clomiphene (Citrate) in Pakistan: