Clofibrate

Drug #185

Clofibrate is antihyperlipidimic agent. Chemically Clofibrate is ethyl 2-(p-chlorophenoxy)-2 methylpropionate. It reduces the high blood cholesterol level.

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Primary Characteristics

Clofibrate is also known as chlorfenicate, clofibate, clofibrats.

It is of Synthetic origin and belongs to Propionic Acid.

It belongs to Lipid lowering agents pharmacological group on the basis of mechanism of action and also classified in Antilipemic Agent , Antilipemic Agent pharmacological group.

Molecular Weight: 242.7 · pK_a: 2.95 · Solubility in Water: insoluble · Solubility in Alcohol: highly soluble · Non-proprietary name: Clofibrate.

Pharmacokinetics

Absorption: Clofibrate has an oral bioavailability is 97% (±2%).

Distribution: Clofibrate has a volume of distribution is 0.1-0.2 l/kg. plasma protein binding is 92-97%.

Elimination: it is metabolised via rapid, plasma, plasma half-life is 18-25 hr, renal excretion is 98%.

Indications

Clofibrate is primarily indicated in conditions like Hypercholesterolaemia, Hyperlipidaemia, Hyperlipidemia, Hyperlipoproteinaemia.

Contraindications

Clofibrate is contraindicated in conditions like Gall stones, Impaired hepatic function, Hypoalbuminaemia, Impaired renal function, Gall bladder disease.

Dosage

Clofibrate's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2 g	2 g	—	PO	indiveded doses.
14.285 mg/kg	14.285 mg/kg	Every 12h	PO
Paediatric Dosage (20kg)
25 mg/kg	25 mg/kg	—	Oral	As Required
Neonatal Dosage (3kg)
0 – 0	—	—		Not used in this age group

Drug Interactions

Unknown12 interactions

1 interaction

Major1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Clofibrate in overdosage may give rise to further complications which include Diarrhoea , Gall stones , Impotence .

Clofibrate produces potentially life-threatening effects which include Cardiac arrhythmias, Cholestasis , Cholisthiasis, Thromboembolic disorders. Careful monitoring is needed with proper medical management.

Clofibrate is known to cause more or less tolerable side effects which are usually transient. These include Alopecia, Nausea, Vomiting , Weakness.

Warnings / Precautions

Withdraw the drug after 3 months if adequate response is not achieved. It should be used with caution in patients with history of liver disease, jaundice or peptic ulcer. Perform complete blood count periodically because anemia and leukopenia have been reported in patients taking clofibrate.

Interference in Pathology

Clofibrate may interfere in the diagnosis of Lower Urinary VMA Excretion. , Raise estimates of serum protein bound iodide & aspartate transaminase. , Increased creatinene phosphokines, decresed alkaline phosphate.

Available Brands

None recorded.

Storage Conditions

Clofibrate should be stored Caps.

Drug Classification

1.12.6 — Lipid-regulating drugs /Anti-atheromas