Clomipramine (HCl)
Clomipramine (HCl) is a tricyclic antidepressant. Clomipramine (HCl) is used in the treatment of (OCD) obsessive compulsive disorders (mental disorder) .
Primary Characteristics
It is of Synthetic origin and belongs to Imipramine.
It belongs to Amine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Antidepressant pharmacological group. It is also classified under Psychotherapeutic Drugs .
Molecular Weight: 351.3 · pKa: 9.5 · Solubility in Water: 1 in 10 · Solubility in Alcohol: 1 in 5 · Non-proprietary name: Clomipramine (HCl) · pH: 10.
Pharmacokinetics
Absorption: Clomipramine (HCl) has an oral bioavailability is 47%, pre-systemic (first-pass) metabolism accounts for 25%.
Distribution: Clomipramine (HCl) has a volume of distribution is 12-17 l/kg. plasma protein binding is 96.5-98.6%.
Elimination: it is metabolised via extensive by liver, plasma half-life is 21 hr, renal excretion is 45-60%.
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Indications
Clomipramine (HCl) is primarily indicated in conditions like Blocking-replacement, Cataplexy, Chronic diarrhoea in adults, Depression, Obsessive-compulsive disorders, Phobic states.
Clomipramine (HCl) is also indicated for secondary conditions like Autism, Pain, Premenstrual syndrome, Stuttering.
Contraindications
Clomipramine (HCl) is contraindicated in conditions like Cardiac arrhythmia, Mania, Myocardial infarction, Heart block, Narrow-angle glaucoma, Hypersensitivity, Urinary retention.
Dosage
Clomipramine (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 137.5 mg/kg | 137.5 mg/kg | Every 24h | PO | Initial, gradually increased |
| Paediatric Dosage (20kg) | ||||
| 200 mg/day | 200 mg/day | Every 24h | ||
| 25 mg | 25 mg | — | PO | initial, gradually incteased.To a maximum of 100mg/kg daily. |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Clomipramine (HCl) in overdosage may give rise to further complications which include Bone marrow depression , Hypertension , Parkinsonism , Extrapyramidal symptoms, Jaundice , Seizures .
Clomipramine (HCl) produces potentially life-threatening effects which include Cardiac Arrest , Mania , Stroke. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Clomipramine (HCl) are Coma, Ataxia, Mydriasis, Hyperactive reflexes, Drowsiness, Convulsions , Restlessness , Vomiting, Tachycardia , Agitation, Impaired impulse conduction, Stupor , Muscular rigidity.
Clomipramine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Altered EEG, Anxiety, Ataxia, Blurred vision, Confusion, Cycloplegia, Delusion, Disorientation, Drowsiness, Erythema, Fatigue, Fever, Giddiness, Hallucination , Headache, Micturition, Mydriasis, Nightmares, Numbness , Palpitation, Paresthesia of extremities, Peripheral neuropathy, Photosensitivity, Pruritus , Reduced salivation, Sedation , Sexual dysfunction, Tingling , Tremors, Weight gain, Xerostomia .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.24.4 — Obsessive -compulsive disorders and panic attacks