Dimethyl Sulfoxide
Also known as: Methyl sulfoxide, Methyl sulfinyl methane, DMSO
DMSO is used as a topical analgesic, a vehicle for topical application of pharmaceuticals, as an anti-inflammatory and an antioxidant. FDA has approved the use of DMSO only for palliative treatment of interstitial cystitis. DMSO also use in the veterinary field as a liniment for horses.Use of DMSO in medicine dates from around 1963, when a University of Oregon Medical School team, headed by Stanley Jacob, discovered it could penetrate deeply through the skin and other membranes without damaging them and could carry other compounds deep into a biological system. Some people report an onion- or garlic-like taste after contact with the skin. This is likely due to catabolic processes which reduce DMSO to dimethyl sulfide. Because DMSO increases the rate of absorption of some compounds through organic tissues including skin, it can be used as a drug delivery system.
Primary Characteristics
Dimethyl Sulfoxide is also known as Methyl sulfoxide, Methyl sulfinyl methane, DMSO.
It is of Synthetic origin.
Molecular Weight: 78.13 · Solubility in Water: Soluble · Solubility in Alcohol: Insoluble · Non-proprietary name: Dimethyl Sulfoxide.

Pharmacokinetics
Elimination: renal excretion is Urine.
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Indications
Dimethyl Sulfoxide is primarily indicated in conditions like Palliative treatment of interstitial cystitis.
Dimethyl Sulfoxide is also indicated for secondary conditions like Arthritic pain, Herpes zoster.
Contraindications
Dimethyl Sulfoxide is contraindicated in conditions like Hypersensitivity to any component of product.
Dosage
Dimethyl Sulfoxide's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0 – 0 | — | — | Intravesical | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Dimethyl Sulfoxide in overdosage may give rise to further complications which include Hypersensitivity reactions , Erythema .
Dimethyl Sulfoxide is known to cause more or less tolerable side effects which are usually transient. These include Burning, Constipation , Diarrhea, Erythema, Headache, Itching, Nausea, Sedation , Vomiting .
Warnings / Precautions
Interference in Pathology
Dimethyl Sulfoxide may interfere in the diagnosis of Liver Function Test (LFT) .
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.12.3.7 — Direct vasodilators