Guanadrel

Drug #1856

Guanadrel belongs to a class of antihypertensive used in the treatment of hypertension.It works by controlling nerve impulses and inhibit norepinephrine as a result relaxes the blood vessels so that blood passes through them easily hence lowering the blood pressure.

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Primary Characteristics

It is of Synthetic origin and belongs to guanidine.

It belongs to Adrenergic Neurone Blockade , Vasodilators pharmacological group on the basis of mechanism of action. It is also classified under Antihypertensive Agents .

Molecular Weight: 213.28 · Solubility in Water: soluble · Solubility in Alcohol: Slightly soluble · Non-proprietary name: Guanadrel · pH: 6.03.

Pharmacokinetics

Absorption: Guanadrel has an pre-systemic (first-pass) metabolism accounts for 42.5% (±42.5%).

Distribution: Guanadrel has a plasma protein binding is <20%.

Elimination: it is metabolised via liver, plasma half-life is 10 hours, renal excretion is 85%.

Indications

Guanadrel is primarily indicated in conditions like Hypertension.

Contraindications

Guanadrel is contraindicated in conditions like Asthma, Heart failure, Peptic ulcer, Stomatitis, Kidney disease.

Dosage

Guanadrel's dosage details are as follows:

Dose	Single Dose	Frequency	Route
Adult Dosage
10 mg	10 mg	Every 12h	Oral
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Guanadrel in overdosage may give rise to further complications which include Allergy , Anxiety , Weight gain , Dizziness , Chest pain , Heart failure , Blurred vision , Constipation .

Guanadrel produces potentially life-threatening effects which include Heart failure. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Guanadrel are Blurred vision, Fainting , Syncope , Orthoststic hypotension.

Guanadrel is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Dizziness, Drowsiness, Fatigue, Fever, Loss of appetite, Nasal congestion , Orthostatic hypotension, Rashes , Swelling of feet.

Warnings / Precautions

Use caution when driving, operating machinery, or performing other hazardous activities. Guanadrel may cause dizziness or drowsiness.Patient should avoid sudden position changes to prevent orthoststic hypotension.

Interference in Pathology

Guanadrel may interfere in the diagnosis of No well documented.

Available Brands

None recorded.

Storage Conditions

Guanadrel should be stored Drug Form.

Drug Classification

1.12.3.7 — Direct vasodilators