DrugInfoSys

Duloxetine Hydrochloride

Drug #1844

Duloxetine hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI) for oral administration. Its chemical designation is (+)-(S)-N-methyl-?-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride. The empirical formula is C18H19NOS•HCl. Duloxetine hydrochloride is a white to slightly brownish white solid, which is slightly soluble in water.

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Primary Characteristics

Duloxetine Hydrochloride is also known as Duloxetine.

It is of Synthetic origin.

Molecular Weight: 333.9 · Non-proprietary name: Duloxetine Hydrochloride · pH: 7.3.

Molecular structure of Duloxetine Hydrochloride

Pharmacokinetics

Distribution: Duloxetine Hydrochloride has a plasma protein binding is 96%.

Elimination: plasma half-life is 8 to 17 hours, renal excretion is Less thab 1%.

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Indications

Duloxetine Hydrochloride is primarily indicated in conditions like Anxiety disorder, Depression, Urinary incontinence.

Duloxetine Hydrochloride is also indicated for secondary conditions like Moderate to severe stress urinary incontinence in women.

Contraindications

None recorded.

Dosage

Duloxetine Hydrochloride's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
50 mg/day50 mg/day—POFor major depression:
60 mg/day60 mg/dayEvery 24hPOFor Diabetic Peripheral Neuropathy
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction
Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Duloxetine Hydrochloride in overdosage may give rise to further complications which include Hyponatremia , Hyponatremia.

Duloxetine Hydrochloride is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Constipation , Decrease in libido, Diarrhea, Dyspepsia , Fatigue, Insomnia, Lethargy, Nausea, Pruritus , Sexual dysfunction, Somnolence , Sweating , Syncope , Thirst, Tremor, Vomiting , Weakness, Weight gain.

Warnings / Precautions

Elderly, History of mania, History of seizures; Raised ocular pressure, Acute narrow- angle glucoma; Concomitant use of drugs that increase risk of bleeding; Suicidal thoughts or behaviour; assess benefit of treatment periodically; avoid abrupt withdrawl. The drug should not be administered to lactating mothers, pregnant mothers and hepatic patients.

Interference in Pathology

Duloxetine Hydrochloride may interfere in the diagnosis of Increased Alkaline Phosphatase , Elevation in ALT or AST.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caps
14 mg20 mg30 mg40 mg60 mg600 mg90 mg
Tabs
30 mg

Multi-Ingredient Combinations

Caps
60 mg

Drug Classification

  1. 1.24.2.1 — Drugs used in depression

Manufacturers