Acemetacin

Also known as: Acemetacinum, Acemetacine

Drug #1793

Acemetacin is a glycolic acid ester of indomethacin, belongs to non-steroidal anti-inflammatory drug (NSAID). Acemetacin is used in the treatment of pain and inflammation in rheumatic disease and other musculoskeletal disorders. Also used for post-operative analgesia.

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Primary Characteristics

Acemetacin is also known as Acemetacinum, Acemetacine.

It is of Synthetic origin.

It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action.

Molecular Weight: 415.82 · Solubility in Water: Insoluble · Solubility in Alcohol: Slightly Soluble · Non-proprietary name: Acemetacin.

Pharmacokinetics

Distribution: Acemetacin has a plasma protein binding is 7.99%.

Indications

Acemetacin is primarily indicated in conditions like Low back pain, Musculoskeletal disorders, Osteoarthritis, Post operative analgesia, Rheumatic arthritis.

Contraindications

Acemetacin is contraindicated in conditions like Cryptococcal meningitis, see instruction.

Dosage

Acemetacin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
150 mg	150 mg	—	PO	120-180mg /day in divided doses
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Acemetacin is known to cause more or less tolerable side effects which are usually transient. These include Confusion, Convulsions , Dizziness, Drowsiness, GI discomfort, GI ulceration, Headache.

Warnings / Precautions

Should be used with caution in the elderly (risk of serious side-effects and fatalities), in allergic disorders, during pregnency and breast feeding, and in coaggulation defects. Caution should be taken in patients with renal, cardiac, or hepatic impairment. Acemetacin should be used with care in epilepsy, parkinsonism, psychiatric disturbances; during prolonged therapy ophthalmic and blood examination perticularly advisable.

Available Brands

None recorded.

Storage Conditions

Acemetacin should be stored caps.

Drug Classification

1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)