Aceclofenac
Also known as: Aceclofenacum
Acelofenac is an analgesic anti-inflammatory drug, belongs to NSAIDs (non-steroidal anti-inflammatory drugs). The actions, uses and adverse effects similar to Diclofenac.
Primary Characteristics
Aceclofenac is also known as Aceclofenacum.
It is of Synthetic origin and belongs to Phenylacetic acid.
It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action.
Molecular Weight: 354.18 · Solubility in Water: insoluble · Solubility in Alcohol: soluble · Non-proprietary name: Aceclofenac.
Pharmacokinetics
Distribution: Aceclofenac has a plasma protein binding is 99%.
Elimination: plasma half-life is 4hrs, renal excretion is 70% to 80%.
Advertisement
Indications
Aceclofenac is primarily indicated in conditions like Ankylosing spondylitis, Muscle relaxation (rapid onset, short duration), Osteoarthritis, Rheumatoid arthritis.
Contraindications
Aceclofenac is contraindicated in conditions like Pregnancy, Breast feeding.
Dosage
Aceclofenac's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 100 mg | 100 mg | Every 12h | PO | Reduce dose to 100 mg in hepatic impairment. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Aceclofenac in overdosage may give rise to further complications which include Lung haemoptysis, Leucocytoclastic vasculitis.
Aceclofenac produces potentially life-threatening effects which include Peptic ulceration, Severe GI bleeding, Hematotoxicity. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Aceclofenac are Dizziness, Nausea, Blurred vision, Headache, Vomiting, Renal failure, Apnea, Coma, Hypotension, Drowsiness, Seizures.
Aceclofenac is known to cause more or less tolerable side effects which are usually transient. These include Aseptic maningitis, Depression, Diarrhea, Dizziness, Drowsiness, Fluid retention, GI discomfort, Headache, Hearing disturbances, Hematuria, Hepatic damage, Hypersensitivity reactions, Insomnia, Nausea, Nephrotic syndrome, nervousness, Pancreatitis, Photosensitivity, Stevens Johnson syndrome, Tinnitus, Toxic epidermal necrolysis, Vertigo.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)