Gallamine Triethiodide

Also known as: Benzcurine Lodide, Gallamone trie thiodide, Gallamini Triethididum

Drug #1791

Gallamine Triethiodide is a benzylisoquinolinium, a competative neuromuscular blocker similar to atracurium. Gallamine Triethiodide is used to produce muscle relaxation in general anaesthesia for surgical procedures and also to assist mechanical ventilation. It has parasympatholytic and sympathomimetic properties and frequently increases pulse rate and blood pressure.

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Primary Characteristics

Gallamine Triethiodide is also known as Benzcurine Lodide, Gallamone trie thiodide, Gallamini Triethididum.

It belongs to Benzyl isoquinolinium.

Molecular Weight: 891.5 · pK_a: 13-14 · Solubility in Water: Very soluble · Solubility in Alcohol: Sparingly Soluble · Non-proprietary name: Gallamine Triethiodide · pH: 5.3.

Molecular structure of Gallamine Triethiodide

Pharmacokinetics

Distribution: Gallamine Triethiodide has a volume of distribution is 280 ml/kg. plasma protein binding is Unknown.

Elimination: plasma half-life is 1.5-4 hr, renal excretion is 95%.

Indications

Gallamine Triethiodide is primarily indicated in conditions like Adjunct to anesthesia, Prophylaxis of NSAID-induced gastric and duodenal ulceration.

Contraindications

Gallamine Triethiodide is contraindicated in conditions like Renal impairment.

Dosage

Gallamine Triethiodide's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1 mg/kg	1 mg/kg	—	IV	For surgery: If necessary, repeated doses of 0.5 to 1 mg/kg or less, at intervals of 50 to 60 minutes or longer, may be given.
50 mg	50 mg	—	IV	Electroconvulsive Therapy
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Gallamine Triethiodide in overdosage may give rise to further complications which include Tachycardia in coronory artery disease patient.

Gallamine Triethiodide produces potentially life-threatening effects which include Acute anaphylactic reactions. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Gallamine Triethiodide are Prolonged muscle paralysis.

Gallamine Triethiodide is known to cause more or less tolerable side effects which are usually transient. These include Difficulty to swallow, Diplopia, Increase in blood pressure, Ptosis, Respiratory depression, Weakness of face + neck muscle.

Warnings / Precautions

Use with caution in patients with hypertension or cardiac insufficiency when tachycardia would be undesirable; it should preferably be avoided in obstetric surgery. Gallamine should be administered by, or under the supervision of, an experienced anesthesiologist. Facilities for intubation, artificial respiration, and oxygen therapy should be available, as well as edrophonium or neostigmine and atropine as antidotes.

Available Brands

None recorded.

Storage Conditions

Gallamine Triethiodide should be stored .

Drug Classification

1.1.4 — Muscle relaxants and cholinesterase inhibitors