Cisatracurium
Cisatracurium is a neuromuscular blocking agent, acts by competing with acetylcholine for receptors on the motor end-plate of the neuromuscular junction to produce blockade. Cisatracurium is a single isomer of atrcurium. Cisatracurium is more potent and has a slightly longer duration of action than atracurium. Cisatracurium is used as a muscle relaxant in general anaesthesia for surgical procedures.
Primary Characteristics
Cisatracurium is also known as Cisatracurium besylate (Cisatrawrium).
It is of Synthetic origin.
Molecular Weight: 929.2 · Non-proprietary name: Cisatracurium · pH: 3.25.
Pharmacokinetics
Distribution: Cisatracurium has a volume of distribution is 0.145l/kg.
Elimination: plasma half-life is 26+/-11min.
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Indications
None recorded.
Contraindications
Cisatracurium is contraindicated in conditions like Hypersensitivity to any component of product.
Dosage
Cisatracurium's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.03 mg/kg | 0.03 mg/kg | — | IV | for intubation and surgery maintanance pf neuromuscular block during peolonged surgical procegures. |
| Paediatric Dosage (20kg) | ||||
| 0.125 mg/kg | 0.125 mg/kg | — | for children 2-12years. | |
| Neonatal Dosage (3kg) | ||||
| 0.15 mg/kg | 0.15 mg/kg | — | over 5 to 10 sec during halothane or opoid anesthesia. (1st month to 23 month) | |
Drug Interactions
None recorded.
Side Effects
The signs and symptoms that are produced after acute overdosage of Cisatracurium are Excessive neuro muscular block.
Cisatracurium is known to cause more or less tolerable side effects which are usually transient. These include Bronchospasm, Hypersensitivity reactions, Hypotension , Skin flushing.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.1.1.1 — Intravenous agents