Mafenide Acetate
Mafenide Acetate is an antibacterial, belongs to sulphonamides. Mafenide Acetate is used topically to prevent bacterial colonisation and infection of burn wounds. Mefenide acetate is absorbed from burn sites, and systemic levels are produced. The drug and its metabolites cause metabolic acidosis, a side effect that limits its usefulness.
Primary Characteristics
It is of Synthetic origin and belongs to Sulfonamides.
Molecular Weight: 246.28 · Solubility in Water: Freely Soluble · Non-proprietary name: Mafenide Acetate.
Pharmacokinetics
Elimination: renal excretion is major.
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Indications
Mafenide Acetate is primarily indicated in conditions like Bacterial infections, Burns.
Contraindications
Mafenide Acetate is contraindicated in conditions like Hypersensitivity to any component of product.
Dosage
Mafenide Acetate's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 5 % | 5 % | — | Topical | Use under moist in burns. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Mafenide Acetate produces potentially life-threatening effects which include Hynolytic Anaemia. Careful monitoring is needed with proper medical management.
Mafenide Acetate is known to cause more or less tolerable side effects which are usually transient. These include Allergic reactions, Hyperventilation , Intense pain at sites of application, Loss of fluid by evaporation from the burn surface, Metabolic acidosis, Urinary alkalosis.
Warnings / Precautions
Interference in Pathology
Mafenide Acetate may interfere in the diagnosis of None well documented.
Available Brands
None recorded.
Drug Classification
- 1.13.2.1 — Antibacterials, topical