Disodium Pamidronate

Drug #1755

Disodium Pamidronate is a bisphosphonate, inhibits bone resorption and thus reduces bone turn over. Disodium Pamidronate is used in the treatment of bone disorders in which excessive bone resorption is a problem, such as paget`s disease of bone and osteoporosis. Disodium Pamidronate is also used as an adjunct insevere hypercalcaemic conditions especially associated with malignancies.

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Primary Characteristics

It is of Synthetic origin.

Molecular Weight: 369 · Non-proprietary name: Disodium Pamidronate.

Molecular structure of Disodium Pamidronate

Pharmacokinetics

Elimination: plasma half-life is 0.8 hr, renal excretion is 54%.

Indications

Disodium Pamidronate is primarily indicated in conditions like Hypercalcaemia due to malignancy, Hypercalcaemia of malignancy, Osteolytic bone metastases, Osteolytic lesions and bone pain, Paget's disease of bone, Sedation with amnesia.

Contraindications

Disodium Pamidronate is contraindicated in conditions like Pregnancy, Breast feeding.

Dosage

Disodium Pamidronate's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
30 mg	30 mg	Every 24h	IV	For paget disease: administered as a 4-hour infusion on 3 consecutive days for a total dose of 90 mg.
75 mg	75 mg	—	IV	Moderate hypercalcemia: Given as a SINGLE-DOSE, intravenous infusion over 2 to 24 hours.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Disodium Pamidronate is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Agitation , Anorexia , Arthralgia, Confusion, Conjunctivitis, Constipation , Diarrhea, Dizziness, dyspepsia, Fatigue, Fever, Flushing, Hallucination , Headache, Hypotension , Influenza like syndrome , Insomnia, Lethargy, Local reaction at injection site, Malaise, Muscle cramps, Myalgia, Nausea and vomiting, Pruritus , Rashes , Rigors , Seizures, Somnolence , Thrombophili, Transient bone pain, Transient rise in body temperature.

Warnings / Precautions

Disodium Pamidronate should be used with caution in patients with cardiac desease with renal impairment---monitor renal function in renal disease or predisposition to renal impairment (e.g in multiple myeloma or tumor induced hypercalcaemia); cardiac disease (especially in elderly); previous thyroid surgery (risk of hypocalcaemia); monitor serum electrolyte, calcium and phosphate---possibility of convulsions due to electrolyte changes; avoid concurrent use with other bisphosphonate. DRIVING: Patients should be warned against driving or operating machinery immediately after treatment (somnolence or dizziness may occur)

Interference in Pathology

Disodium Pamidronate may interfere in the diagnosis of Abnormal LFTs .

Available Brands

None recorded.

Drug Classification

1.18.14 — Drugs affecting bone metabolism