Disodium Etidronate

Drug #1754

Disodium Etidronate is a bisphosphonate, inhibits bone resorption and thus reduces bone turn over. Disodium Etidronate is used in the treatment of bone disorders in which excessive bone resorption is a problem, such as paget`s disease of bone and osteoporosis. Disodium Etidronate is also used as an adjunct insevere hypercalcaemic conditions especially associated with malignancies.

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Primary Characteristics

It belongs to Bisphosphonate.

Molecular Weight: 250 · Non-proprietary name: Disodium Etidronate.

Molecular structure of Disodium Etidronate

Pharmacokinetics

Elimination: plasma half-life is 1-6 hour, renal excretion is 50%.

Indications

Disodium Etidronate is primarily indicated in conditions like Osteoporosis, Paget's disease of bone, Sedation with amnesia, Severe hypercalcaemia.

Contraindications

Disodium Etidronate is contraindicated in conditions like Pregnancy, Breast feeding, Pain and inflammation (rheumatic disease), Vasomotor symptoms in estrogen deficiency, see instruction.

Dosage

Disodium Etidronate's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
7.5 mg/kg/day	7.5 mg/kg/day	Every 24h	PO	For paget disease: Dose should not to exceed 6 mo.For retreatment, initiate only after etidronate-free period of at least 90 days and if there is evidence of active disease.
20 mg/kg/day	20 mg/kg/day	—	PO	Heterotopic Ossification from Spinal Cord Injury: This dose is given for 2 wk followed by 10 mg/kg/day for 10 wk. Total treatment period is 12 wk.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Disodium Etidronate is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Constipation , Diarrhea, Headache, Increased bone pain in paget`s disease, Nausea, Pruritus , Skin reactions, Urticaria.

Warnings / Precautions

Disodium Etidronate should be used with caution in renal impairment (reduce dose in mild, avoid if moderate to severe). MONITORING: Serum phosphate, serum alkaline phosphatase and (if possible) urinary hydroxyproline should be measured before starting and at intervals of 3 months---consult product literature for further information. COUNSELLING: Avoid food for atleast 2 hours before and after oral treatment perticularly calcium-containing products e.g milk; also avoid iron and mineral supplements and antacids.

Available Brands

None recorded.

Drug Classification

1.18.14 — Drugs affecting bone metabolism