Insulin Aspart

Drug #1748

Insulin Aspart is a recombinant human insulin analogue. Insulin Aspart is used in the treatment of diabetes mellitus. It has a faster onset and shorter duration of action than soluble insulin.

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Primary Characteristics

Non-proprietary name: Insulin Aspart.

Pharmacokinetics

None recorded.

Indications

Insulin Aspart is primarily indicated in conditions like Diabetes mellitus.

Contraindications

Insulin Aspart is contraindicated in conditions like Hypoglycaemia, Hypersensitivity to any component of product.

Dosage

Insulin Aspart's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.5 – 0.8 units/kg/day	—	—	SC	For Diabetes Mellitus Type I: Initial dose
0.2 – 0.5 units/kg/day	—	—	SC	For Diabetes Mellitus Type I: Honeymoon phase
0.1 units/kg/day	0.1 units/kg/day	—	SC	Dose for Diabetes Mellitus Type II: Conventional regimen: Initial dose, monotherapy:
0.85 units/kg/day	0.85 units/kg/day	—	SC	For Diabetes Mellitus Type I: Split dose therapy:
1 units/kg/day	1 units/kg/day	—	SC	Dose for Diabetes Mellitus Type II: Intensive regimen: Initial dose, monotherapy:
1.6 units/kg/day	1.6 units/kg/day	—	SC	For Diabetes Mellitus Type I: Insulin resistance:
2 units/kg/day	2 units/kg/day	—	SC	For Diabetes Mellitus Type I:Conventional regimen: Maintenance dose, monotherapy:
2.5 units/kg/day	2.5 units/kg/day	—	SC	For Diabetes Mellitus Type I:Intensive regimen: Maintenance dose, monotherapy:
6 Units	6 Units	Every 12h	SC	This is the initial dose for type II diabetic patients; when it is available in premixed form (Soluble insulin aspart/protamine-crystallised insulin aspart: 100 U/ml in the ratio of 30/70). Give at breakfast and dinner.
6 Units	6 Units	Every 24h	SC	This is the initial dose for type II diabetic patients; when it is available in premixed form (Soluble insulin aspart/protamine-crystallised insulin aspart: 100 U/ml in the ratio of 30/70). Give at dinner. When using 30 units once daily, it is generally recommended to move to twice-daily when reaching 30 units by splitting the dose into equal breakfast and dinner doses. If twice daily dosing with 30 units results in recurrent daytime hypoglycaemic episodes, the morning dose can be split into morning and lunchtime doses (thrice daily dosing).
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Insulin Aspart is known to cause more or less tolerable side effects which are usually transient. These include Fat hypertrophy at injection site, Local reactions, Swelling of feet.

Warnings / Precautions

The human insulin analogues, insulin lispro and insulin aspart, have a faster onset of action and shorter duration of action than soluble insulin; as a result, compared to soluble insulin, fasting and preprandial blood-glucose concentration is a little higher, postprandial blood-glucose concentration is a little lower, and hypoglycaemia occurs slightly less frequently. Insulin aspart should be used with caution in patients with renal impairment (May need dose reduction).

Interference in Pathology

Insulin Aspart may interfere in the diagnosis of Monitoring of blood and urine glucose.

Available Brands

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Single Ingredient

Inj

100 IU

Multi-Ingredient Combinations

Inj

30 %

Drug Classification

1.18.7.1 — Insulins

Manufacturers

Manufacturers of Insulin Aspart in Pakistan:

Nova Novo