Ertapenem
Ertapenem is a broad spectrum beta-lactam antibiotic. Ertapenem is active against gram +ve and gram -ve and anaerobes. Ertapenem is used parentrally in the treatment of abdominal and gynaecological infections and in community-acquired pneumonia.
Primary Characteristics
Ertapenem is also known as Ertapenem Na.
It is of Synthetic origin.
Molecular Weight: 497.5 · pKa: 4.05 · Solubility in Water: Soluble as sodium salt · Non-proprietary name: Ertapenem.
Pharmacokinetics
Absorption: Ertapenem has an oral bioavailability is 45% (±45%).
Distribution: Ertapenem has a volume of distribution is 0.12l/kg. plasma protein binding is 95%.
Elimination: plasma half-life is 4 Hours, renal excretion is 80% Urine.
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Indications
Ertapenem is primarily indicated in conditions like Community acquired pneumonia, Gynaecologic infections, Intra-abdominal infections, Skin infections, Urinary tract infection.
Contraindications
Ertapenem is contraindicated in conditions like Breast feeding.
Dosage
Ertapenem's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1 g | 1 g | Every 24h | IV | For Infection Prophylaxis: Prophylaxis of surgical site infection following elective colorectal surgery:Should be given one hour prior to surgical incision |
| 1 g | 1 g | Every 24h | IV/IM | For Intraabdominal Infection: Should be given for 5 to 14 days |
| 1 g | 1 g | Every 24h | IV/IM | For Pelvic Infections: for 3 to 10 days |
| 1 g | 1 g | Every 24h | IV/IM | For Pyelonephritis: The recommended total duration of antibiotic treatment is 10 to 14 days, which includes a possible conversion to oral therapy after at least 3 days of parenteral therapy and once clinical improvement occurs. |
| 1 g | 1 g | Every 24h | IV/IM | For Urinary Tract Infection: The recommended total duration of antibiotic treatment is 10 to 14 days, which includes a possible conversion to oral therapy after at least 3 days of parenteral therapy and once clinical improvement occurs. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Ertapenem in overdosage may give rise to further complications which include Blood clot in vein, Collapsed portion of lung, Decrease Neutrophills.
Ertapenem is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , Antibiotic-associated colitis, Diarrhea, Dizziness, Dry mouth, Dyspepsia , Headache, Hypotension , Injection-site reactions, Nausea and vomiting, Pruritus , Raised platelet count, Rashes .
Warnings / Precautions
Interference in Pathology
Ertapenem may interfere in the diagnosis of Liver Function Test (LFT) .
Available Brands
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Single Ingredient
Drug Classification
- 1.6.2.1.4 — Other inhibitors of cell wall synthesis
Manufacturers
Manufacturers of Ertapenem in Pakistan: