DrugInfoSys

Co-Fluampicil

Drug #1722

Co-Fluampicil is a mixture of equal parts by mass of flucloxacillin and ampicillin, used to produce a wider spectrum of activity. Ampicillin is a beta-lactam antibiotic active against certain gram +ve and gram -ve organisms, but is inactivated by penicillinases. Flucloxacillin, however, is a penicillinase-resistant antibiotic and thus effective in infections caused by penicillin-resistant staphylococci.

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Primary Characteristics

Non-proprietary name: Co-Fluampicil.

Molecular structure of Co-Fluampicil

Pharmacokinetics

None recorded.

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Indications

Co-Fluampicil is primarily indicated in conditions like Schizophrenia and other psychoses.

Contraindications

Co-Fluampicil is contraindicated in conditions like Penicillin hypersensitivity.

Dosage

Co-Fluampicil's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
250 mg/day250 mg/dayEvery 6hPOShould be taken 1 hour before meal.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Co-Fluampicil is known to cause more or less tolerable side effects which are usually transient. These include Anaphylaxis, Angioedema, Antibiotic-associated colitis, Cholestatic Jaundice , Convulsions (especially with high doses or in severe renal impairment), Diarrhea, Fever, Hemolytic anemia, Hepatitis, Hypersensitivity reactions, Interstitial nephritis, Joint pain, Neutropenia, Rashes , Thrombocytopenia, Urticaria.

Warnings / Precautions

Co-Fluampicil should be used with caution in patients with history of allergy; erythematous rash common in grandular fever; cytomegalovirus infections; acute or chronic lymphocytic leukaemia; renal impairment (reduce dose if severe); porphyria; cholestatic jaundice. CSM has advised that cholestatic jaundice may occur up to several weeks after treatment with Co-Fluampicil has been stopped.Administration for more than 2 weeks and increasing age are risk factors.

Available Brands

None recorded.

Drug Classification

  1. 1.6.2.1.1 — Penicillins