Reteplase

Drug #1672

Reteplase is a parenteral 3rd generation thrombolytic agent. Reteplase is a recombinant plasminogen activator (r-PA), converts plasminogen to plasmin, a proteolytic enzyme which has fibrinolytic properties. It creates a generalised lytic state when administered intravenously. Thus, both protective hemostatic thrombi and target thromboemboli are broken down. Reteplase is indicated in the management of coronary occlusion in acute myocardial infarction (AMI). Reteplase is also used for the treatment of multiple pulmonary emboli that are not massive enough to require surgical management and in cases of central deep vein thrombosis. It was approved by FDA in october, 1996.

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Primary Characteristics

It is of Semi Synthetic origin.

Non-proprietary name: Reteplase.

Pharmacokinetics

None recorded.

Indications

Reteplase is primarily indicated in conditions like Acute myocardial infarction.

Contraindications

None recorded.

Dosage

Reteplase's dosage details are as follows:

Dose	Single Dose	Frequency	Route
Adult Dosage
0.625 unit/hr	0.625 unit/hr	—	IV
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Reteplase produces potentially life-threatening effects which include Ventricular fibrillation, Arrhythmias, Cardiac Arrest , Pericarditis , Ventricular tachycardia. Careful monitoring is needed with proper medical management.

Reteplase is known to cause more or less tolerable side effects which are usually transient. These include Bleeding , Cardiac failure, Intracranial hemorrhage, Tachycardia.

Warnings / Precautions

This medication may cause bleeding. Use caution with sharp objects like safety razors or nail cutters and avoid activities which that may increase your chance of getting cut, bruised, or injured. Also, avoid unnecessary injections into the muscles (IM). Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug. This medication should be used only when clearly needed during pregnancy.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inj

10 IU

Drug Classification

1.12.5 — Anti-thrombotic drugs and myocardial infarction

Manufacturers

Manufacturers of Reteplase in Pakistan:

Excel