Chlorprothixene

Also known as: Alpha-chlorprothixiene, Cis-chlorprothixeve, Chlothixen

Drug #167

Chlorprothixene is a thioxanthene drug having sedative, antiemetic, antihistaminic, anticholinergic and a-adrenergic blocking activity. Chlorprothixene is administered orally or by intramuscular injection.

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Primary Characteristics

Chlorprothixene is also known as Alpha-chlorprothixiene, Cis-chlorprothixeve, Chlothixen.

It is of Synthetic origin and belongs to Thioxanthene.

It belongs to D2 antagonist pharmacological group on the basis of mechanism of action and also classified in Antipsychotic Agent pharmacological group. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 315.9 · pK_a: 8.4 · Solubility in Water: 1 in 1700 · Solubility in Alcohol: 1 in 29 · Non-proprietary name: Chlorprothixene.

Pharmacokinetics

Absorption: Chlorprothixene has an oral bioavailability is 31.5% (±11.5%), pre-systemic (first-pass) metabolism accounts for 40% (±35%).

Distribution: Chlorprothixene has a volume of distribution is 15.5 l/kg or >7l/kg. plasma protein binding is >99%.

Elimination: it is metabolised via hepatic, plasma half-life is 9.4 hr, renal excretion is >12%.

Indications

Chlorprothixene is primarily indicated in conditions like Agitation, Mania, Psychosis, Schizophrenia.

Chlorprothixene is also indicated for secondary conditions like Anxiety, Herpetic neuralgia.

Contraindications

Chlorprothixene is contraindicated in conditions like Circulatory collapse, Coma.

Dosage

Chlorprothixene's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
100 mg/kg	100 mg/kg	Every 8h	IV,IM
32.5 mg	32.5 mg	Every 6h	PO	dose up to 600mg or more in severe cases.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
0.7 mg/kg	0.7 mg/kg	Every 24h		usaual single dose to a total of 100mg/day (over age 6}.

Drug Interactions

Unknown3 interactions

3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Chlorprothixene in overdosage may give rise to further complications which include Tardive dyskinesia , Seizures , Systemic lupus erythematosus .

Chlorprothixene produces potentially life-threatening effects which include Obstructive Jaundice , Neuroleptic Malignant Syndrome , Neuroleptic malignant syndrome. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Chlorprothixene are Hypotension, Tachycardia , Cardiac arrhythmias, Seizures, Cardiodepression, Respiratory arrest, Reduced peristalsis of GIT, Acute oliguria.

Chlorprothixene is known to cause more or less tolerable side effects which are usually transient. These include Acute dystonia, Akathisia, Extra pyramidal symptoms, Hypotension , Induction of hostility , Nausea and vomiting, Parkinsonism, Sedation , Skin rashesX.

Warnings / Precautions

Chlorprothixene should be used with caution in patients exposed to extreme heat or phosphorus insecticides, patients in state of alcohol withdrawal, patients with history of peptic ulcer, allergic reactions, with renal impairment, prostatic hypertrophy. Photosensitization may occur, caution patients to take appropriate measure (e.g.wear protective clothing or sunscreen) against exposure to sunlight or UV light. Discontinue use atleast 48 hours before myelography.

Available Brands

None recorded.

Storage Conditions

Chlorprothixene should be stored Tab.

Drug Classification

1.24.1 — Drugs used in psychotic disorders