Chlorpropamide

Drug #166

Chlorpropamide is oral hypoglycemic agent. Chlorpropamide is used in the treatment of non-insulin dependent diabetes mellitus. Chlorpropamide is used in conjunction with proper diet and exercise to decrease blood sugar levels.

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Primary Characteristics

Chlorpropamide is also known as chloropropamide, , .

It is of Synthetic origin and belongs to Sulfonylurea.

It belongs to Potassium Channel (ATP sensitive) antagonist pharmacological group on the basis of mechanism of action and also classified in Antidiabetic Agent, Sulfonylurea pharmacological group. It is also classified under Drugs Afecting Glucose Metabolism .

Molecular Weight: 277 · pK_a: 5.0 · Solubility in Water: < 1 in 10000 · Solubility in Alcohol: 1 in 12 · Non-proprietary name: Chlorpropamide.

Pharmacokinetics

Absorption: Chlorpropamide has an oral bioavailability is 100%, pre-systemic (first-pass) metabolism accounts for 9%.

Distribution: Chlorpropamide has a volume of distribution is 0.14-0.21 l/kg. plasma protein binding is 57-96%.

Elimination: it is metabolised via extensive by Liver 80%, plasma half-life is 24-48hr, renal excretion is major.

Indications

Chlorpropamide is primarily indicated in conditions like Diabetes insipidus, Diabetes mellitus, Diabetes mellitus type-ii.

Chlorpropamide is also indicated for secondary conditions like Softening and dilatation of cervix before mechanical cervical dilatation.

Contraindications

Chlorpropamide is contraindicated in conditions like Iddm, Ketosis, Congestive heart failure, Renal impairment, Hepatic impairment, Gestational diabetes mellitus.

Dosage

Chlorpropamide's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
75 mg	75 mg	Every 24h	Orally	Maintanance dose.1-2 divided doses 5-7 days after the initial therapy
250 mg	250 mg	Every 24h	PO	With breakfast.
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
187.5 mg	187.5 mg	Every 24h		For central D.I.

Drug Interactions

Unknown10 interactions

5 interactions

Minor2 interactions

Moderate13 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Chlorpropamide in overdosage may give rise to further complications which include Thrombocytopenia , Cholestatic jaundice , Aplastic anemia , Hemolytic anemia , Cholestatic jaundice , Aplastic anemia , Hemolytic anemia , Fictitious hypoglycemia, Agranulocytosis , Exfoliative dermatitis , Eosinophilic pulmonary infiltrates , Hemolytic anemia, Aplastic anemia.

Chlorpropamide produces potentially life-threatening effects which include Hypoglycemia , Hypoglycemia, Hypoglycemia. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Chlorpropamide are Coma, Seizures, Hypothermia, Hypoglycemia.

Chlorpropamide is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Diarrhea, Dyspepsia , Facial flushing, Headache, Hyponatremia.

Warnings / Precautions

Chlorpropamide should be used with caution in patients with medical history, especially if have high blood pressure or liver or kidney disease. Avoid alcohol while taking this medication. Photosensitization may occur, caution patients to take appropriate measure (e.g.wear protective clothing and a sunscreen) against exposure to UV or sunlight. It should be used in pregnancy or lactation only if clearly needed. Insulin therapy may be necessary during pregnancy.

Available Brands

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Single Ingredient

Tabs

250 mg

Storage Conditions

Chlorpropamide should be stored Tab.

Drug Classification

1.18.7.2 — Oral hypoglycemics

Manufacturers

Manufacturers of Chlorpropamide in Pakistan:

Geofman Jinnah Pfizer Zafa