DrugInfoSys

Candesartan

Drug #1658

Candesartan belongs to the unique class of antihyptensive agents called angiotensin II (AG II) receptor antagonists. The actions and uses are similar to those of Losartan.Its derivative Candesartan cilexetil is given orally in the treatment of hypertension, alone or in combination with other antihypertensive drugs. Candesartan like other angiotensin II receptor antagonist doesnot inhib Candesartan cilexetil the breakdown of bradykinins, and thus doesnot appear to cause persistant dry cough which complecates ACE inhibitor therapy, therefore Candesartan cilexetil is a useful alternative for patients who have to discontinue an ACE inhibitor because of persistant cough.

← Previous drugNext drug →

Primary Characteristics

Candesartan is also known as Candesartan Cilexetil.

It is of Synthetic origin.

Non-proprietary name: Candesartan.

Molecular structure of Candesartan

Pharmacokinetics

Absorption: Candesartan has an oral bioavailability is 45% (±11%).

Distribution: Candesartan has a volume of distribution is 0.13l/kg. plasma protein binding is 99.8%.

Elimination: plasma half-life is 9.7hr, renal excretion is 52%.

Advertisement

Indications

Candesartan is primarily indicated in conditions like Hypertension.

Candesartan is also indicated for secondary conditions like Diabetic nephropathy, Heart failure.

Contraindications

Candesartan is contraindicated in conditions like Cholestasis, Pregnancy, Breast feeding.

Dosage

Candesartan's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
8 mg8 mgEvery 24hPOAdjusted a/c to response. Max. 16 mg once daily.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Candesartan is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Arthralgia, Back pain, Headache, Influenza like syndrome , Myalgia, Nausea, Rashes , Respiratory tract infections.

Warnings / Precautions

Hepatic and renal impairment; use with caution in renal artery stenosis, aortic or mitral valve stenosis and in obstructive hypertrophic cardiomyopathy.Monitor plasma-potassium concentration, particularly in elderly and in patients with renal impairment; lower initial doses may be appropriate in these patients.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs
16 mg32 mg4 mg8 mg

Multi-Ingredient Combinations

Tabs
16 mg32 mg

Storage Conditions

Candesartan should be stored Tabs.

Drug Classification

  1. 1.12.3.4 — Angiotensin II receptor anatgonists

Manufacturers