Irbesartan
Irbesartan is an antihypertensive agent, belongs to angiotensin II receptor antagonists. The actions, uses and adverse effects are similar to those of losartan. Irbesartan is used either alone or in combination with other antihypertensive agents for the management of hypertension and other cardiovascular disorders.
Primary Characteristics
It belongs to Angiotensin II Rantasonist.
It belongs to Angiotensin-II receptor antagonist pharmacological group on the basis of mechanism of action.
Molecular Weight: 428.53 · Solubility in Water: insoluble · Solubility in Alcohol: slightly soluble · Non-proprietary name: Irbesartan.
Pharmacokinetics
Absorption: Irbesartan has an oral bioavailability is 70% (±10%).
Distribution: Irbesartan has a volume of distribution is 0.72l/kg. plasma protein binding is 96%.
Elimination: it is metabolised via By liver (cyp 2C9) to isact,Metabolism, plasma half-life is 13(6.8-19.2)hr, renal excretion is 2.2(1.3-3.1)%.
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Indications
Irbesartan is primarily indicated in conditions like Hypertension.
Irbesartan is also indicated for secondary conditions like Diabetic nephropathy, Heart failure, Renal disease in hypertensive type ii diabetes mellitus.
Contraindications
Irbesartan is contraindicated in conditions like Pregnancy, Breast feeding.
Dosage
Irbesartan's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 300 mg | 300 mg | Every 24h | Type diabetes.Initially & hypertension Maintanance. | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Irbesartan in overdosage may give rise to further complications which include Hyperkalemia , Impaired renal function , Myelgia.
The signs and symptoms that are produced after acute overdosage of Irbesartan are Dizziness, Fast & slow heart beat.
Irbesartan is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Angioedema, Chest pain, Confusion, Dizziness, Edema, Fatigue, Headache, Hypotension , Nausea and vomiting, Pharyngitis, Rashes , Rhinitis , Tachycardia, UTI .
Warnings / Precautions
Interference in Pathology
Irbesartan may interfere in the diagnosis of Increased level of Blood urea nitrogen (BUN) concentrations, Increased in serum creatinin.
Available Brands
Storage Conditions
Drug Classification
- 1.12.3.4 — Angiotensin II receptor anatgonists