Chlormethiazole (Edisylate)

Also known as: Clomethiazole (Edisylate)

Drug #161

Chlormethiazole (Edisylate) sedatve and anticonvulsant agent. Chlormethiazole (Edisylate) used for sedation in agitated or confused patoent especially the elderly. italso used for treatment of acute withdrawal symptoms in alcoholics and for control of epileptic fits.

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Primary Characteristics

Chlormethiazole (Edisylate) is also known as Clomethiazole (Edisylate).

It is of Synthetic origin and belongs to Thiazole.

It belongs to Chloride Channel opener (Gaba operated) pharmacological group on the basis of mechanism of action.

Molecular Weight: 161.7 · pK_a: 3.3 · Solubility in Water: > 1 in 100 · Solubility in Alcohol: miscible · Non-proprietary name: Chlormethiazole (Edisylate).

Molecular structure of Chlormethiazole (Edisylate)

Pharmacokinetics

Absorption: Chlormethiazole (Edisylate) has an oral bioavailability is 97% (±2%), pre-systemic (first-pass) metabolism accounts for 67.5% (±27.5%).

Distribution: Chlormethiazole (Edisylate) has a volume of distribution is 8-19 l/kg. plasma protein binding is 60-69%.

Elimination: it is metabolised via extensive by liver, plasma half-life is 4-12 hr, renal excretion is major.

Indications

Chlormethiazole (Edisylate) is primarily indicated in conditions like Agitation, Alcohol withdrawal, Delirium tremens, Insomnia, Pre-eclamptic toxaemia, Regional anaesthesia, Severe insomnia (short-term use), Status epilepticus, Urinary frequency.

Chlormethiazole (Edisylate) is also indicated for secondary conditions like Muscle relaxation, Parkinson's disease.

Contraindications

Chlormethiazole (Edisylate) is contraindicated in conditions like Pulmonary insufficiency.

Dosage

Chlormethiazole (Edisylate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
288 mg/ml	288 mg/ml	Every 24h	PO	At bed time.
Paediatric Dosage (20kg)
0.08 mg/kg.min	0.08 mg/kg.min	—	IV Infusion	As Required, dose may be gradually increased
Neonatal Dosage (3kg)
0.08 mg/kg/min	0.08 mg/kg/min	Every 24h	Infusion	As required

Drug Interactions

Unknown4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Chlormethiazole (Edisylate) in overdosage may give rise to further complications which include Dependency .

Chlormethiazole (Edisylate) produces potentially life-threatening effects which include Respiratory arrest, Anaphylactic reactions. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Chlormethiazole (Edisylate) are Coma, pneumonia, Respiratory depression, Hypothermia, Respiratory depression, Hypertension, Respiratory depression.

Chlormethiazole (Edisylate) is known to cause more or less tolerable side effects which are usually transient. These include Conjunctival irritation, Headache, Nasal congestion , Skin rashesX, Sneezing, Thrombophlebitis .

Warnings / Precautions

Patients should observe caution while driving or performing other tasks requiring alertness, because it may cause drowsiness. Avoid use in patient with acute pulmonary insufficiency. Chlormethiazole should be used with caution in patients with chronic pulmonary insufficiency, renal (kidney), liver, cerebral or cardiac disease and respiratory disease.

Interference in Pathology

Chlormethiazole (Edisylate) may interfere in the diagnosis of Increase activity of glycine.

Available Brands

None recorded.

Storage Conditions

Chlormethiazole (Edisylate) should be stored Cap, IV Inf, Oral soln.

Drug Classification

1.24.1 — Drugs used in psychotic disorders