Hepatitis B Immunoglobulin
Hepatitis B Immunoglobulin is a sterile liquid freez-dried preparation containing immunoglobulins, mainly immunoglobulin G (IgG), derived from the plasma from selected immunised donors having specific antibodies against hepatitis B surface antigen. Hepatitis B immunoglobulins are used for the passive immunisation of persons expose or possibly exposed to hepititis B virus.
Primary Characteristics
It is of Natural origin.
Non-proprietary name: Hepatitis B Immunoglobulin.
Pharmacokinetics
Elimination: plasma half-life is 22 days.
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Indications
Hepatitis B Immunoglobulin is primarily indicated in conditions like Prevention of hepatitis B, after exposure.
Contraindications
Hepatitis B Immunoglobulin is contraindicated in conditions like Hypersensitivity.
Dosage
Hepatitis B Immunoglobulin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 500 IU | 500 IU | — | IM | As soon as possible after exposure. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Hepatitis B Immunoglobulin is known to cause more or less tolerable side effects which are usually transient. These include Chills, Facial flushing, Fever, Headache, Hypersensitivity , Nausea.
Warnings / Precautions
Interference in Pathology
Hepatitis B Immunoglobulin may interfere in the diagnosis of Misleading + results in serological testing, Interferes with serological tests for red cell anti bodies e.g coombs test..
Available Brands
Storage Conditions
Drug Classification
- 1.19.2.9 — Hepatitis B immunoglobulins
Manufacturers
Manufacturers of Hepatitis B Immunoglobulin in Pakistan: