Nisoldipine

Drug #1547

Nisoldipine is a calcium-channel antagonist with actions and uses similar to those of nifedipine. It belongs to dihydropyridine class of calcium-channel antagonist that includes nifedipine, amlodipine, felodipine isradipine. In general, the dihydropyridine-type calcium-channel antagonists have more prominent effects on vasodilation and coronary flow than do diltiazem and verapamil. Nisoldipine is used in the treatment of Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon.

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Primary Characteristics

It is of Synthetic origin and belongs to Dihydophyidine calcium autogoust.

Molecular Weight: 388.4 · Solubility in Water: 1 in 50000 · Solubility in Alcohol: 1 in 30000 · Non-proprietary name: Nisoldipine.

Pharmacokinetics

Absorption: Nisoldipine has an oral bioavailability is 6% (±2%), pre-systemic (first-pass) metabolism accounts for 47.5% (±47.5%).

Distribution: Nisoldipine has a volume of distribution is 4 - 6 l/kg. plasma protein binding is 99.7 %.

Elimination: plasma half-life is 7-12 hr, renal excretion is 0.1 % (unchanged), 90 % (as metabolite).

Indications

Nisoldipine is primarily indicated in conditions like Angina, Hypertension, Mild to moderate hypertension, Prophylaxis of angina.

Contraindications

Nisoldipine is contraindicated in conditions like Shock, Cardiac failure, Pulmonary hypertension, Aortic stenosis, Hepatic dysfunction, Hypersensitivity, Pregnancy, Lactation.

Dosage

Nisoldipine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
8.5 – 34 mg	—	Every 24h	PO	For Angina Pectoris Prophylaxis, Hypertension: Maintenance dose:
10 mg	10 mg	Every 24h	PO	For Angina Pectoris Prophylaxis, Hypertension: Initial dose
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown2 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Nisoldipine produces potentially life-threatening effects which include Myocardial infarction, Worsening angina. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Nisoldipine are Heart failure. , Bradyarrhythmias, Hypotension.

Nisoldipine is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Flushing, Headache, Hot swollen legs and feets, Palpitation, Tiredness .

Warnings / Precautions

It should be used with caution in patients with kidney or liver disease. Consider decrease in dose of calcium channel blockers and monitor drug response in cirrhosis patients.

Available Brands

None recorded.

Storage Conditions

Nisoldipine should be stored Tab.

Drug Classification

1.12.3.2 — Calcium antagonists