Nicorandil
Nicorandil is a derivative of nicotinamide, acts as a vasodilator and facilitates the opening of potassium-channels. It produces vasodilation of arterioles and large coronary arteries, while the nitrate component produces venous vasodilatation. Nicorandil is used in the management of angina pectoris.
Primary Characteristics
It is of Synthetic origin.
Molecular Weight: 211.2 · pKa: 3.18 · Solubility in Water: 1 in 66 · Solubility in Alcohol: 1 in 7.5 · Non-proprietary name: Nicorandil.
Pharmacokinetics
Absorption: Nicorandil has an oral bioavailability is 50% (±50%).
Distribution: Nicorandil has a volume of distribution is ~ 1 l/Kg. plasma protein binding is 25 %.
Elimination: plasma half-life is 1 hr, renal excretion is 20%.
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Indications
Nicorandil is primarily indicated in conditions like Acute heart failure, Stable angina pectoris, Unstable angina.
Contraindications
Nicorandil is contraindicated in conditions like Cardiogenic shock, Hypotension, Left ventricular failure, Additional vascular conditions.
Dosage
Nicorandil's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 200 mg/kg | 200 mg/kg | — | Continous IV infusion | Over 5mints |
| 20 mg | 20 mg | Every 12h | Oral | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Nicorandil in overdosage may give rise to further complications which include Hepatic function abnormilities.
The signs and symptoms that are produced after acute overdosage of Nicorandil are Hypotension.
Nicorandil is known to cause more or less tolerable side effects which are usually transient. These include Angioedema, dizziness, Fatigue, Flushing, Headache, Hypotension, Malaise, Myalgia, Nausea, Palpitation, Skin rash, Vomiting , Weakness.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.12.1 — Antianginal drugs