Quinagolide (HCl)

Drug #1543

Quinagolide (HCl) is an non-ergot dopamine receptor antagonist, the actions and uses are similar to those of bromocriptine. Quinagolide (HCl) is used in the treatment of such disorders associated with hyperprolactinaemia.

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Primary Characteristics

It is of Synthetic origin.

Molecular Weight: 432 · pK_a: 7.65 +/- 0.15 · Solubility in Water: 1 in 420 · Solubility in Alcohol: 1 in 710 · Non-proprietary name: Quinagolide (HCl).

Molecular structure of Quinagolide (HCl)

Pharmacokinetics

Absorption: Quinagolide (HCl) has an oral bioavailability is 50% (±50%), pre-systemic (first-pass) metabolism accounts for 47.5% (±47.5%).

Distribution: Quinagolide (HCl) has a volume of distribution is 100 litre. plasma protein binding is 90 %.

Elimination: it is metabolised via > 95 % (Liver), plasma half-life is 11.5 hr.

Indications

Quinagolide (HCl) is primarily indicated in conditions like Adjuvant therapy in acromegaly, Hyperprolactinaemia.

Contraindications

Quinagolide (HCl) is contraindicated in conditions like Depression, Impaired hepatic function, Psychiatric disease, Impaired renal function, Mental illness, Pregnancy.

Dosage

Quinagolide (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
112.5 mcg/day	112.5 mcg/day	—	PO	Single patients may require daily doses of 300 micrograms or higher. In such cases, the daily dosage may be increased in steps of 75 micrograms to 150 micrograms at intervals not shorter than 4 weeks until satisfactory therapeutic effectiveness is achieved or reduced tolerability limits further increases in the dose.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown7 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Quinagolide (HCl) in overdosage may give rise to further complications which include Sexual disinhibition, Hypomania , Psychiatric disease.

The signs and symptoms that are produced after acute overdosage of Quinagolide (HCl) are Bradycardia, Hypotension, Drowsiness, Nausea, Vomiting, Collapse, Dizziness, Headache, Anxiety .

Quinagolide (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , Constipation , Diarrhea, Dizziness, Fatigue, Flushing, Headache, Hypotension , Insomnia, Nasal congestion , Nausea, Vomiting , Weight LossX.

Warnings / Precautions

It should be used cautiously in patients with history of heart attack, angina , liver or kidney disease, psychiatric illness or circulation problems in the fingers in cold weather. This medication should be used only when clearly needed during pregnancy. This drug is not recommended during lactation.

Available Brands

None recorded.

Storage Conditions

Quinagolide (HCl) should be stored Tab.

Drug Classification

1.9.1 — Drugs used in parkinsonism