Terlipressin
A vasopressin analogue, which is used to control bleeding from esophageal varices . It is administered intravenously.
Primary Characteristics
It is of Synthetic origin and belongs to Peptide.
Molecular Weight: 1227.4 · Solubility in Water: freely · Solubility in Alcohol: freely · Non-proprietary name: Terlipressin.
Pharmacokinetics
Distribution: Terlipressin has a volume of distribution is 0.7 l/kg.
Elimination: plasma half-life is 24 min, renal excretion is < 0.1 % unchanged.
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Indications
Terlipressin is primarily indicated in conditions like Bleeding from oesophageal varices, Bleeding oesophageal varices.
Contraindications
Terlipressin is contraindicated in conditions like Vascular disease.
Dosage
None recorded.
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Terlipressin in overdosage may give rise to further complications which include Angina , Cardiac arrhythmias, Abdominal cramps.
Terlipressin produces potentially life-threatening effects which include Bradycardia , Myocardial infarction, Cardiac failure. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Terlipressin are Hypertension, Increase in BP , Water retention.
Terlipressin is known to cause more or less tolerable side effects which are usually transient. These include Abdominal cramps, Headache, Nausea, Skin pallor, Weakness of the leg.
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.10.5 — Drugs used in esophageal varices bleeding