Diprophylline
Diprophylline is a derivative of theophyline, used as a bronchodilator. The action and uses are similar to those of theophyline.
Primary Characteristics
It is of Synthetic origin.
Molecular Weight: 254.2 · Solubility in Water: Freely · Solubility in Alcohol: Sparingly · Non-proprietary name: Diprophylline · pH: 5.
Pharmacokinetics
Distribution: Diprophylline has a plasma protein binding is 40 %.
Elimination: plasma half-life is 2 hour.
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Indications
Diprophylline is primarily indicated in conditions like Airway obstruction, Apnoea, Bronchospasm.
Diprophylline is also indicated for secondary conditions like Asthma, Obstructive airway disease.
Contraindications
None recorded.
Dosage
Diprophylline's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 15 mg/kg of body weight | 15 mg/kg of body weight | Every 6h | PO | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Diprophylline in overdosage may give rise to further complications which include Cardiac arrhythmias, Hypotension , Convulsions , Gynecomastia.
The signs and symptoms that are produced after acute overdosage of Diprophylline are Death , Vomiting, Diuresis, Hypotension, Tachycardia , Cardiac arrhythmias, Convulsions , Dehydration, Hematemesis, Agitation.
Diprophylline is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anxiety, Diarrhea, Dizziness, GI irritation, Headache, Insomnia, Nausea and vomiting, Palpitation, Restlessness, Tremor.
Warnings / Precautions
Interference in Pathology
Diprophylline may interfere in the diagnosis of Pulmonary function test.
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.25.1.1 — Oral/Parenteral antiasthmatics