Azapropazone

Drug #1533

Azapropazone is a non-steroidal anti-inflammatory drug (NSAID). Azapropazone is a weak inhibitor of cyclooxygenase, but possesses potent uricosuric activity, therefore particularly useful for the treatment of acute gout. Azapropazone is also used for the treatment of rheumatoid arthritis, osteoarthritis.

← Previous drug Next drug →

Primary Characteristics

It is of Synthetic origin.

Molecular Weight: 300.4 · Solubility in Water: slighty · Solubility in Alcohol: soluble · Non-proprietary name: Azapropazone.

Pharmacokinetics

Elimination: plasma half-life is 12 - 16 hr, renal excretion is 65% (unchanged).

Indications

Azapropazone is primarily indicated in conditions like Acute gout attack, Rheumatoid arthritis.

Contraindications

Azapropazone is contraindicated in conditions like Peptic ulcer, Blood disorders.

Dosage

Azapropazone's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
600 mg	600 mg	Every 12h	PO	The dose can be decreased to 900mg/day and incresed upto 1800mg/day. For renal impaired function: Starting dose is 300mg in the morning and 600 mg at night. For much older patients(more than 65 years):Starting dose is 600mg at night or 300 mg twice daily.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown7 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Azapropazone in overdosage may give rise to further complications which include Pulmonary fibrosis , Agranulocytosis , Hepatitis , Erythema multiforme.

Azapropazone produces potentially life-threatening effects which include Coombs +ve hemolytic anemia, Autoimmune hemolysis, Acute intestinal nephritis, Non-oliguric renal failure. Careful monitoring is needed with proper medical management.

Azapropazone is known to cause more or less tolerable side effects which are usually transient. These include Photosensitivity.

Warnings / Precautions

It should not be given in patient with peptic ulceration and should be used with caution in patient with a history of such disorders and with infection, asthma or allergic disorder, impaired renal, hepatic or cardiac function, in elderly and may need to be given in reduce doses. To reduce he risk of gastrointestinal effects, the drug may be taken with or after food or milk.

Available Brands

None recorded.

Storage Conditions

Azapropazone should be stored Caps, Tabs.

Drug Classification

1.2.3 — Antigout preparations