DrugInfoSys

Penbutolol

Drug #1524

Penbutolol is a medication in the class of beta blockers used in treatment of hypertension.<BR>Penbutolol (Sulphate) is a non-cardioselective beta-blocker. Penbutolol (Sulphate) is used in the management of hypertension and angina pectoris.

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Primary Characteristics

Penbutolol is also known as Penbutolol (Sulphate).

It is of Synthetic origin.

Molecular Weight: 680.9 · pKa: 9.3 · Solubility in Water: slighty · Solubility in Alcohol: slighty · Non-proprietary name: Penbutolol (Sulphate).

Molecular structure of Penbutolol

Pharmacokinetics

Absorption: Penbutolol has an oral bioavailability is 50% (±50%).

Distribution: Penbutolol has a volume of distribution is 5.1 l/kg. plasma protein binding is > 95 %.

Elimination: plasma half-life is 1.4 hr, renal excretion is 4 % unchanged.

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Indications

Penbutolol is primarily indicated in conditions like Hypertension.

Penbutolol is also indicated for secondary conditions like Angina.

Contraindications

Penbutolol is contraindicated in conditions like Bronchospasm, Cardiac failure, Haemorrhage, Heart block, Bradycardia, Low cardiac output, Hypersensitivity.

Dosage

Penbutolol's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
25 mg25 mgEvery 24hPO
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown4 interactions
Major1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Penbutolol in overdosage may give rise to further complications which include Depression , Bleeding , Chest pain .

Penbutolol produces potentially life-threatening effects which include Bradycardia , Hypoglycemia , Hypotension, Bronchospasm , Cardiogenic shock. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Penbutolol are Hypotension, Bradycardia, Cardiogenic shock, Convulsions , Slow heartbeat.

Penbutolol is known to cause more or less tolerable side effects which are usually transient. These include Cough , Diarrhea, Dizziness, Fatigue, Headache, Nausea, Sweating , Tiredness .

Warnings / Precautions

It should be used with caution in diabetic patients and patients with kidney or liver disease.Donot drive because Penbutolol may cause dizziness. Penbutolol tends to decrease blood circulation in skin,fingers and toes.Dress warmly during cold weather. Stay out of direct sunlight.Cautions should be taken in allergic patients.

Available Brands

None recorded.

Storage Conditions

Penbutolol should be stored Tab.

Drug Classification

  1. 1.12.3.1 — Beta blocking agents