Riluzole
Riluzole is a glutamate antagonist used for the treatment of amyotrophic lateral sclerosis, a form of motor neuron disease which produces muscular atrophy and weakness.
Primary Characteristics
It is of Synthetic origin.
Molecular Weight: 234.2 · Solubility in Water: Insoluble · Non-proprietary name: Riluzole.
Pharmacokinetics
None recorded.
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Indications
Riluzole is primarily indicated in conditions like Motor neuron disease.
Contraindications
Riluzole is contraindicated in conditions like Neutropenia, Pregnancy, Lactation, Increase liver transaminase.
Dosage
Riluzole's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 50 mg | 50 mg | Every 6h | PO | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Riluzole produces potentially life-threatening effects which include Neutropenia . Careful monitoring is needed with proper medical management.
Riluzole is known to cause more or less tolerable side effects which are usually transient. These include Abdominal distress, Anorexia , Asthenia , Dizziness, Headache, Hypertonia, Nausea, Pain , Tachycardia, Vomiting .
Warnings / Precautions
Interference in Pathology
Riluzole may interfere in the diagnosis of Abnormal LFTs , Increased Alkaline Phosphatase Levels, +ve Coomb`s tests.
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.5 — Anticonvulsants and Antiepileptics