Ropinirole (HCl)
Ropinirole (HCl) is a dopamine receptor agonist, used for the treatment of Parkinson`s disease. Ropinirole (HCl) is also used with levodopa in more advanced disease. It may also be used for the treatment of moderate-to-severe primary Restless Legs Syndrome (RLS) in adults,
Primary Characteristics
Ropinirole (HCl) is also known as Ropinirole .
It is of Synthetic origin.
Molecular Weight: 296.8 · pKa: 9.5 · Solubility in Water: 1 in 7520 · Solubility in Alcohol: 1 in 340 · Non-proprietary name: Ropinirole (HCl).
Pharmacokinetics
Absorption: Ropinirole (HCl) has an oral bioavailability is 47.5% (±47.5%), pre-systemic (first-pass) metabolism accounts for 25% (±25%).
Distribution: Ropinirole (HCl) has a volume of distribution is ~ 7 l/kg. plasma protein binding is < 39 %.
Elimination: plasma half-life is ~ 6 hr, renal excretion is 88 - 90 %.
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Indications
Ropinirole (HCl) is primarily indicated in conditions like Idiopathic parkinsons disease.
Contraindications
Ropinirole (HCl) is contraindicated in conditions like Hypersensitivity, Pregnancy, Lactation.
Dosage
Ropinirole (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.25 mg | 0.25 mg | Every 8h | PO | Initial dose for 1st week. |
| 0.5 mg | 0.5 mg | Every 8h | PO | Dose for 2nd week. |
| 0.75 mg | 0.75 mg | Every 8h | PO | Dose for 3rd week. |
| 1 mg | 1 mg | Every 8h | PO | Dose for 4th week. After week 4, if necessary, daily dosage may be increased by 1.5 mg/day on a weekly basis up to a dose of 9 mg/day, and then by up to 3 mg/day weekly to a total dose of 24 mg/day |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Ropinirole (HCl) in overdosage may give rise to further complications which include Psychosis , Depression , Confusion , Cardiac arrhythmias, Amnesia, Postural hypotension , Anxiety , Hallucinations .
The signs and symptoms that are produced after acute overdosage of Ropinirole (HCl) are Dizziness, Confusion , Nausea, Agitation, Orthostatic hypotension, Chest pain, Vomiting, Dystonia.
Ropinirole (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Confusion, Leg edema, Nausea, Vomiting .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.9.1 — Drugs used in parkinsonism