Cephradine
Also known as: Cefradine
Cephradine is a first generation, semisynthetic analogue of natural cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Cephradine is effective against gram positive and gram negative bacterias. Administered orally or by intramuscularly or by intravenous injection. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cephradine is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.
Primary Characteristics
Cephradine is also known as Cefradine.
It is of Semi Synthetic origin and belongs to Cephalosporin.
It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin pharmacological group.
Molecular Weight: 349.4 · pKa: 2.6, 7.3 · Solubility in Water: highly soluble · Solubility in Alcohol: insoluble · Non-proprietary name: Cephradine.
Pharmacokinetics
Absorption: Cephradine has an oral bioavailability is 75% (±5%).
Distribution: Cephradine has a volume of distribution is 0.29 ± 0.03 l/kg. plasma protein binding is <10%.
Elimination: it is metabolised via insignificant, plasma half-life is 0.7 hr (oral), 2-3 hr (IM).
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Indications
Cephradine is primarily indicated in conditions like Bone and joint infection, Genitourinary tract infections, Lower respiratory tract infections, Pharyngitis, Pneumonia, Prostatitis, Respiratory tract infections, Skin infections, Soft tissue infections, Surgical prophylaxis, Tonsillitis, Upper respiratory tract infections.
Cephradine is also indicated for secondary conditions like Bacterial infections.
Contraindications
Cephradine is contraindicated in conditions like Hypersensitivity.
Dosage
Cephradine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 3 g | 3 g | — | IV /IM | Over 3-5 min (in 4 divided doses),(up to 8g daily inverse infections. |
| 1.5 g | 1.5 g | Every 6h | P/O | 2-4 divided doses (up to 4g) |
| 1.5 g | 1.5 g | — | PO | For surgical prophylaxis |
| Paediatric Dosage (20kg) | ||||
| 31.25 mg/kg | 31.25 mg/kg | — | IV/IM | For Paeds of All Ages . given in 4 divided doses .This dose is for severe infections.(to maximum of |
| 62.5 mg/kg | 62.5 mg/kg | Every 24h | P/O | Otilis media |
| 37.5 mg/kg | 37.5 mg/kg | — | PO | Given in 2-4 divided doses |
| Neonatal Dosage (3kg) | ||||
| 9.4 mg/kg | 9.4 mg/kg | Every 6h | oral | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Cephradine in overdosage may give rise to further complications which include Pseudomembranous colitis , Hypersensitivity reactions , Seizures , Superinfection .
Cephradine produces potentially life-threatening effects which include Anaphylactic reactions, Thrombophelebitis. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Cephradine are Nausea, Severe diarrhea, Convulsions .
Cephradine is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Local pain, Nausea, Skin rashes, Vaginitis.
Warnings / Precautions
Interference in Pathology
Cephradine may interfere in the diagnosis of False positive reactions to Fehlings or Benedicts Reagents .
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.6.2.1.3 — Cephalosporins
Manufacturers
Manufacturers of Cephradine in Pakistan: