Cephazolin (Na)
Cephazolin is a first-generation cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Cephazolin is effective in a large variety of bacterial infections, such as respiratory tract, skin and urinary tract infections. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cephazolin (Na) is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.
Primary Characteristics
Cephazolin (Na) is also known as Cephazolin.
It is of Semi Synthetic origin and belongs to Cephalosporin.
It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.
Molecular Weight: 476.5 · pKa: 2.1 · Solubility in Water: high · Non-proprietary name: Cephazolin (Na).
Pharmacokinetics
Distribution: Cephazolin (Na) has a volume of distribution is 9.2 litre. plasma protein binding is 74-86%.
Elimination: it is metabolised via Nil, plasma half-life is 1.8 hr, renal excretion is major.
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Indications
Cephazolin (Na) is primarily indicated in conditions like Bacterial infections, Bone and joint infection, Endocarditis, Genitourinary tract infections, Peritonitis, Persistant neutropenia in advanced hiv infection, Respiratory tract infections, Septicaemia, Skin infections, Soft tissue infections.
Cephazolin (Na) is also indicated for secondary conditions like Biliary tract disorders, Bronchiectasis, Bronchogenic carcinoma, Pneumonia.
Contraindications
Cephazolin (Na) is contraindicated in conditions like Pregnancy, Hypersensitivity to any component of product.
Dosage
Cephazolin (Na)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 750 mg /kg | 750 mg /kg | Every 12h | IV,IM | 6 to 12g is used in sevire infection. |
| Paediatric Dosage (20kg) | ||||
| 37.5 mg/kg | 37.5 mg/kg | Every 8h | Intra Muscular | Maximum of 100mg/kg. |
| 37.5 mg/kg | 37.5 mg/kg | Every 8h | Intra Venous | Maximum of 100mg/kg. |
| Neonatal Dosage (3kg) | ||||
| 12.49 gm | 12.49 gm | Every 8h | Intravenous | Not recommended for children under 1 month |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Cephazolin (Na) in overdosage may give rise to further complications which include Convulsions , Thrombocytopenia , Hypersensitivity reactions , Eosinophilia , Eosinophilia , Leucopenia, Neutropenia .
Cephazolin (Na) produces potentially life-threatening effects which include Pseudomembranous colitis , Anaphylactic reactions. Careful monitoring is needed with proper medical management.
Cephazolin (Na) is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Diarrhea, Genital and anal pruritus, Genital moniliasis, Nausea, Rise in blood urea levels, Transient rise in SGPT & SGOT .
Warnings / Precautions
Interference in Pathology
Cephazolin (Na) may interfere in the diagnosis of False +ve Coombs Test , Reversed phase HPLC method for the analysis of theophylline , Positve Coombs test, interfere with cross matching of Blood , False + ve reaction to benedicts & fehling reagents.
Available Brands
Storage Conditions
Drug Classification
- 1.6.2.1.3 — Cephalosporins