Cephalothin (Na)

Also known as: Cefalotin Sodium

Drug #150

Cephalothin is a first generation, semisynthetic analogue of natural cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Cephalothin is effective against gram positive and gram negative bacterias. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cephalothin (Na) is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.

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Primary Characteristics

Cephalothin (Na) is also known as Cefalotin Sodium.

It is of Semi Synthetic origin and belongs to Cephalosporin.

It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.

Molecular Weight: 418.4 · pK_a: 2.2 · Solubility in Water: 1 in 3.5 · Solubility in Alcohol: 1 in 700 · Non-proprietary name: Cephalothin (Na) · pH: 8.5 · Isotonic value: 6.8.

Pharmacokinetics

Distribution: Cephalothin (Na) has a volume of distribution is 0.26 l/kg. plasma protein binding is 65%.

Elimination: it is metabolised via hepatic, plasma half-life is 0.57 hr, renal excretion is >65%.

Indications

Cephalothin (Na) is primarily indicated in conditions like Bone and joint infection, CVS infections, Genitourinary tract infections, Respiratory tract infections, Soft tissue and skin infections.

Cephalothin (Na) is also indicated for secondary conditions like Peritonitis, Septic abortion, Surgical prophylaxis.

Contraindications

Cephalothin (Na) is contraindicated in conditions like Hypersensitivity.

Dosage

Cephalothin (Na)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.5 – 1 g	—	Every 6h	IV inf	Up to 12 g in severe infections
Paediatric Dosage (20kg)
120 mg/kg	120 mg/kg	Every 4h	Intra Venous	Up to 12g daily in serve infection.
Neonatal Dosage (3kg)
20 mg/kg	20 mg/kg	Every 8h	Intravenous

Drug Interactions

Unknown3 interactions

2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Cephalothin (Na) in overdosage may give rise to further complications which include Nephrotoxicity , Hemolytic anemia .

Cephalothin (Na) produces potentially life-threatening effects which include Anaphylaxis , Serum sickness syndrome. Careful monitoring is needed with proper medical management.

Cephalothin (Na) is known to cause more or less tolerable side effects which are usually transient. These include Allergic reactions, Pain at injection site, Rashes , Thrombophlebitis , Urticaria.

Warnings / Precautions

Cephalothin should be used with caution in patients with impaired kidney or liver function. Appropriate measure should be taken if secondary infection occurs. It should be used with caution (if contains tartrazine) in patients with aspirin hypersensitivity, because it may cause allergic reactions (including bronchial asthma).

Interference in Pathology

Cephalothin (Na) may interfere in the diagnosis of False Positive Coombs Test associated with hemolytic anemia. , Estimation of Serum Creatinine using Jaffe method. , False +ve reaction for urinary glucose using benedicts/Fehling slon..

Available Brands

None recorded.

Storage Conditions

Cephalothin (Na) should be stored IV Inj, IV Inf.

Drug Classification

1.6.2.1.3 — Cephalosporins