Rimantadine

Drug #1508

Rimantadine is an oral antiviral agent. Rimantadine is indicated for the prophylaxis and treatment of influenza A virus infections in adults and for prophylaxis only in children. Rimantadine is chemically and structurally related to amantadine, but it lacks the central nervous system effects seen with amantadine. It was approved for use in September 1993.

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Primary Characteristics

It is of Synthetic origin.

Molecular Weight: 215.8 · Non-proprietary name: Rimantadine.

Pharmacokinetics

Distribution: Rimantadine has a plasma protein binding is 40%.

Elimination: plasma half-life is 24-36 hr, renal excretion is 25% (unchanged).

Indications

Rimantadine is primarily indicated in conditions like Influenza.

Contraindications

Rimantadine is contraindicated in conditions like Hypersensitivity to any component of product.

Dosage

Rimantadine's dosage details are as follows:

Dose	Single Dose	Frequency	Route
Adult Dosage
100 mg	100 mg	Every 12h	PO
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Rimantadine is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , GI disturbance, Insomnia, Light headedness, Nausea and vomiting, Nervousness, Nightmares.

Warnings / Precautions

It should be used with caution in patients with epilepsy. Doses should be reduced in renal or hepatic failure. Reduced doses have also been used in th elderly.

Available Brands

None recorded.

Storage Conditions

Rimantadine should be stored Oral Syrup, Tab.

Drug Classification

1.6.5.2 — Antiretroviral drugs