Ritonavir
Ritonavir is an antiretroviral agent belongs to the group of known as protease inhibitors, but ritonavir has improved oral bioavailability compared with other protease inhibitors. Ritonavir is used either alone, or in combination with nucleoside reverse transcriptase inhibitor, for the treatment of progressive or advanced HIV infection.
Primary Characteristics
Molecular Weight: 720.9 · Non-proprietary name: Ritonavir.
Pharmacokinetics
Distribution: Ritonavir has a volume of distribution is 0.41(0.16-0.66)l/kg. plasma protein binding is 98 %.
Elimination: it is metabolised via Liver, plasma half-life is 3 - 5 hr, renal excretion is 3.5(1.7-5.3)%.
Advertisement
Indications
Ritonavir is primarily indicated in conditions like Chronic lymphocytic leukaemia, HIV infection, Schizophrenia and other psychoses.
Contraindications
None recorded.
Dosage
Ritonavir's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 600 mg | 600 mg | Every 12h | PO | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Ritonavir in overdosage may give rise to further complications which include Orthostatic hypotension , Vasodilation , Syncope , Myalgia , Renal insufficiency.
Ritonavir is known to cause more or less tolerable side effects which are usually transient. These include Asthenia , Diarrhea, Dizziness, Fatigue, Headache, Nausea and vomiting, Pruritus , Skin RashX, Taste disturbance.
Warnings / Precautions
Available Brands
Click on a strength to view available brands.
Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.6.5.2 — Antiretroviral drugs
Manufacturers
Manufacturers of Ritonavir in Pakistan: