Succimer

Drug #1504

Succimer is 2, 3- dimercaptosuccinic acid (DMSA), a chelating (binding)agent Succimer is used to treat lead poisoning.

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Primary Characteristics

It is of Synthetic origin.

Molecular Weight: 182.2 · Non-proprietary name: Succimer.

Pharmacokinetics

None recorded.

Indications

Succimer is primarily indicated in conditions like Arsenic poisoning, Lead poisoning, Mercury poisoning.

Contraindications

Succimer is contraindicated in conditions like Hypersensitivity to any component of product.

Dosage

Succimer's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
10 mg/kg	10 mg/kg	—	PO	Start dosage at 10 mg/kg or 350 mg/m2 every eight hours for five days. Initiation of therapy at higher doses is not recommended. Reduce frequency of administration to 10 mg/kg or 350 mg/m2 every 12 hours (two-thirds of initial daily dosage) for an additional two weeks of therapy. A course of treatment lasts 19 days. Repeated courses may be necessary if indicated by weekly monitoring of blood lead concentration.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Succimer in overdosage may give rise to further complications which include Mild to modrate neutropenia.

Succimer is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Drowsiness, Flu like syndrome, GI disorders, Increase in serum transaminase, Skin RashX.

Warnings / Precautions

It should be used with caution in patients with impaired renal function or with a history of hepatic disorder.

Interference in Pathology

Succimer may interfere in the diagnosis of Elevations of SGPT and SGOT , False +ve test for Ketone bodies in Urine , Increased Alkaline Phosphatase Levels, Increased serum cholesterol, Falsely decreased measurements of CPK, Falsely decreased measurements of serum uric acid.

Available Brands

None recorded.

Storage Conditions

Succimer should be stored Caps.

Drug Classification

1.4.2.5 — Lead poisoning