Divalproex (Na)

Drug #1503

Divalproex (Na) is a synonym of semisodium valproate (an united states approved name USAN), an antiepileptic used perticularly in the treatment of primary generalised seizures, and also for partial seizures. its action are complex and its mode of action is not fully understood. Divalproex (Na) is also used to treat the acute manic attacksand for the prophylaxis of migraine.

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Primary Characteristics

Divalproex (Na) is also known as Valproate semisodium.

It is of Synthetic origin.

Molecular Weight: 310.4 · Non-proprietary name: Divalproex (Na).

Pharmacokinetics

Distribution: Divalproex (Na) has a plasma protein binding is 90-95 %.

Elimination: it is metabolised via Liver, plasma half-life is 5-20 hr.

Indications

Divalproex (Na) is primarily indicated in conditions like Generalized seizures, Partial seizures.

Contraindications

Divalproex (Na) is contraindicated in conditions like Liver diseases.

Dosage

Divalproex (Na)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
750 mg	750 mg	Every 24h	PO	For mania
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Divalproex (Na) in overdosage may give rise to further complications which include Thrombocytopenia , Leucopenia, Bone marrow depression .

Divalproex (Na) is known to cause more or less tolerable side effects which are usually transient. These include Edema, Headache, Increased appetite, Weight gain.

Warnings / Precautions

It should be used with caution in patients with liver disease, bleeding disorder, history of a brain disorder or any allergy. It should be used with caution while driving motor vehicles or performing tasks that require alertness. Before having surgery, including dental surgery, inform the doctor about the use of drug. This may interfere with urine ketone testing and give false positive results, if very high sugar readings (e.g. over 300) are occurring, ketones may be present in urine, contact the doctor or pharmacist. It should be used with extreme caution in children under 2 years old as serious liver problems exist. The drug is not recommended for use during pregnancy or lactation. Treatment should be stopped if pancreatitis is tecognized.

Interference in Pathology

Divalproex (Na) may interfere in the diagnosis of Altered thyroid function test.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs

250 mg 500 mg

Storage Conditions

Divalproex (Na) should be stored Caps, Tab. Inj.

Drug Classification

1.5 — Anticonvulsants and Antiepileptics

Manufacturers

Manufacturers of Divalproex (Na) in Pakistan:

Gray's Hansel Polyfine Valor