Oxycodone

Drug #1501

Oxycodone is a phenantherne derivative with opiod analgesic activity similar to morphine but adverse effects are milder than those of morphine. Oxycodone is used to control moderate to severe pain, including postoperative, postextractional, and postpartum pain. it, and other opiates such as morphine and codeine act as agonists at opiate receptors within the central nervous system (CNS). Opiate receptors include µ (mu), ? (kappa), d (delta), and s (sigma) and function as inhibitory modulators of synaptic transmission in both the CNS and the myenteric plexus.Clinically, stimulation of µ and ? receptors produces analgesia, euphoria, respiratory depression, miosis, decreased gastrointestinal motility, and physical dependence. It was approved by the FDA in 1976 and is a schedule C-II controlled substance.

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Primary Characteristics

Oxycodone is also known as Oxycodone Terephthalate.

It is of Synthetic origin.

Molecular Weight: 351.8 · Solubility in Water: soluble · Solubility in Alcohol: slighty · Non-proprietary name: Oxycodone.

Pharmacokinetics

None recorded.

Indications

Oxycodone is primarily indicated in conditions like Moderate to moderately severe pain, Moderate to severe pain.

Contraindications

Oxycodone is contraindicated in conditions like Peptic ulcer, Platelet dysfunction, Liver damage, Bleeding, Hypersensitivity to the drug.

Dosage

None recorded.

Drug Interactions

Unknown5 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Oxycodone in overdosage may give rise to further complications which include Hallucinations , Anaphylactic reactions .

The signs and symptoms that are produced after acute overdosage of Oxycodone are Pulmonary edema , Convulsions , Coma, Respiratory depression, Respiratory depression, Renal failure.

Oxycodone is known to cause more or less tolerable side effects which are usually transient. These include Confusion, Constipation , Dizziness, Drowsiness, Dry mouth, Nausea and vomiting, Restlessness.

Warnings / Precautions

Oxycodone should be given with caution or in reduced doses to patients with hypothyroidism, adrenocortical insufficiency, asthma or decreased respiratory reserve, renal or hepatic impairment, prostatic hyperplasia, hypotension, shock, inflammatory or obstructive bowel disorders, or myasthenia gravis. Dosage should be reduced in elderly or debilitated patients. Oxycodone should be given with great care to infants, especially neonates. Their use during labour may cause respiratory depression in the neonate. Discontinuation of therapy with Oxycodone should be carried out gradually in patients who may have developed physical dependence, to avoid precipitating withdrawal symptoms. Drowsiness may affect the ability to perform skilled tasks; those so affected should not drive or operate machinery.

Available Brands

None recorded.

Storage Conditions

Oxycodone should be stored Tab, Cap, Oral Soln.

Drug Classification

1.2.2 — Opioid analgesics